Protein Information

General Information
MoonProt ID250
First appeared in release1.0
Name(s)Ubp6 Ubiquitin carboxyl-terminal hydrolase 6 Deubiquitinating enzyme 6 Ubiquitin thioesterase 6 Ubiquitin-specific-processing protease 6 Gene Name: UBP6
UniProt IDP43593 (UBP6_YEAST), Reviewed
GO termsGO:0006508 proteolysis GO:0006511 ubiquitin-dependent protein catabolic process GO:0016579 protein deubiquitination GO:1901799 negative regulation of proteasomal protein catabolic process GO:0004843 ubiquitin-specific protease activity GO:0008233 peptidase activity GO:0008234 cysteine-type peptidase activity GO:0016787 hydrolase activity GO:0000502 proteasome complex GO:0005838 proteasome regulatory particle GO:0031144 proteasome localization GO:0044257 cellular protein catabolic process GO:0042176 regulation of protein catabolic process
Organisms for which functions have been demonstratedSaccharomyces cerevisiae
Sequence length499
FASTA sequence>sp|P43593|UBP6_YEAST Ubiquitin carboxyl-terminal hydrolase 6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBP6 PE=1 SV=1 MSGETFEFNIRHSGKVYPITLSTDATSADLKSKAEELTQVPSARQKYMVKGGLSGEESIKIYPLIKPGSTVMLLGTPDANLISKPAKKNNFIEDLAPEQQVQQFAQLPVGFKNMGNTCYLNATLQALYRVNDLRDMILNYNPSQGVSNSGAQDEEIHKQIVIEMKRCFENLQNKSFKSVLPIVLLNTLRKCYPQFAERDSQGGFYKQQDAEELFTQLFHSMSIVFGDKFSEDFRIQFKTTIKDTANDNDITVKENESDSKLQCHISGTTNFMRNGLLEGLNEKIEKRSDLTGANSIYSVEKKISRLPKFLTVQYVRFFWKRSTNKKSKILRKVVFPFQLDVADMLTPEYAAEKVKVRDELRKVEKEKNEKEREIKRRKFDPSSSENVMTPREQYETQVALNESEKDQWLEEYKKHFPPNLEKGENPSCVYNLIGVITHQGANSESGHYQAFIRDELDENKWYKFNDDKVSVVEKEKIESLAGGGESDSALILMYKGFGL
Structure Information
PDB ID1VJV
Quaternary structure
Function 1
Function descriptiondeubiquitinase, enzyme associated with proteasome releases ubiquitin from ubiquitinated proteins that bind to the proteasome
References for functionPark, Kyung Chan, et al. "Purification and Characterization of UBP6, a New Ubiquitin-Specific Protease inSaccharomyces cerevisiae." Archives of biochemistry and biophysics 347.1 (1997): 78-84.
E.C. number3.4.19.12
Location of functional site(s)active site: 118, 447
Cellular location of functioncytoplasm, part of proteasome
Comments
Function 2
Function descriptioninhibits proteasome activity delays the degradation of ubiquitinated proteins by the proteasome enables gradual deubiquitination of the substrate
References for functionHanna J, Hathaway NA, Tone Y, Crosas B, Elsasser S, Kirkpatrick DS, Leggett DS, Gygi SP, King RW, Finley D. Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation. Cell. 2006 Oct 6. PMID: 17018280
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm, part of proteasome
Comments