Protein Information

General Information
MoonProt ID251
First appeared in release1.0
Name(s)Epidermal retinol dehydrogenase 2 hRoDH-E2 EPHD-2 RDH-E2 Retinal short-chain dehydrogenase reductase 2 retSDR2 Short-chain dehydrogenase/reductase family 16C member 5 Gene Name: SDR16C5
UniProt IDQ8N3Y7 (RDHE2_HUMAN), Reviewed
GO termsGO:0008152 metabolic process GO:0042572 retinol metabolic process GO:0042574 retinal metabolic process GO:0043616 keratinocyte proliferation GO:0050908 detection of light stimulus involved in visual perception GO:0055114 oxidation-reduction process GO:0004745 retinol dehydrogenase activity GO:0016491 oxidoreductase activity GO:0005783 endoplasmic reticulum GO:0005789 endoplasmic reticulum membrane GO:0016020 membrane GO:0016021 integral component of membrane GO:0006351 transcription, DNA-templated
Organisms for which functions have been demonstratedHomo sapiens
Sequence length309
FASTA sequence>sp|Q8N3Y7|RDHE2_HUMAN Epidermal retinol dehydrogenase 2 OS=Homo sapiens GN=SDR16C5 PE=2 SV=2 MSFNLQSSKKLFIFLGKSLFSLLEAMIFALLPKPRKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQKGIKTTIVCPFFIKTGMFEGCTTGCPSLLPILEPKYAVEKIVEAILQEKMYLYMPKLLYFMMFLKSFLPLKTGLLIADYLGILHAMDGFVDQKKKL
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionretinol dehydrogenase, enzyme all-trans-retinol + NAD+ <=> all-trans-retinal + NADH. Cofactor metabolism, retinol metabolism
References for functionHsu, Lily C., Chang Wen-Chung, and Akira Yoshida. "Genomic structure of the human cytosolic aldehyde dehydrogenase gene." Genomics 5.4 (1989): 857-865.
E.C. number1.1.1.105
Location of functional site(s)binding site: 177; active site: 190; nucleotide binding: 44-68
Cellular location of functionEndoplasmic reticulum, transmembrane protein
Comments
Function 2
Function descriptiontranscriptional repressor represses profilaggrin promoter activity by adjusting the activity of Sp1 and other activators
References for functionMarkova NG, PinkasSarafova A, Simon M. A metabolic enzyme of the short-chain dehydrogenase/reductase superfamily may moonlight in the nucleus as a repressor of promoter activity. J Invest Dermatol. 2006 Sep. PMID: 16691198
E.C. numberN/A
Location of functional site(s)
Cellular location of functionnucleus
Comments