Protein Information

General Information
MoonProt ID252
First appeared in release1.0
Name(s)Pyruvate kinase PKM Pyruvate kinase muscle isozyme Gene Name: Pkm
UniProt IDP11980 (KPYM_RAT), Reviewed
GO termsGO:0001666 response to hypoxia GO:0001889 liver development GO:0006006 glucose metabolic process GO:0006096 glycolytic process GO:0006754 ATP biosynthetic process GO:0007584 response to nutrient GO:0008152 metabolic process GO:0009629 response to gravity GO:0010033 response to organic substance GO:0014870 response to muscle inactivity GO:0016310 phosphorylation GO:0031100 organ regeneration GO:0032868 response to insulin GO:0042866 pyruvate biosynthetic process GO:0043403 skeletal muscle tissue regeneration GO:0000166 nucleotide binding GO:0000287 magnesium ion binding GO:0003824 catalytic activity GO:0004743 pyruvate kinase activity GO:0005515 protein binding GO:0005524 ATP binding GO:0016301 kinase activity GO:0016740 transferase activity GO:0030955 potassium ion binding GO:0043531 ADP binding GO:0046872 metal ion binding GO:0005634 nucleus GO:0005737 cytoplasm GO:0070324 thyroid hormone binding
Organisms for which functions have been demonstratedRattus norvegicus
Sequence length531
FASTA sequence>sp|P11980|KPYM_RAT Pyruvate kinase PKM OS=Rattus norvegicus GN=Pkm PE=1 SV=3 MPKPDSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADYLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAVFHRLLFEELARASSQSTDPLEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLDAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionPyruvate kinase, enzyme ATP + pyruvate => ADP + phosphoenolpyruvate Carbohydrate degradation, glycolysis enzyme as tetramer
References for functionParkison C, Ashizawa K, McPhie P, Lin KH, Cheng SY. The monomer of pyruvate kinase, subtype M1, is both a kinase and a cytosolic thyroid hormone binding protein. Biochem Biophys Res Commun. 1991 Aug 30. PMID: 1883388
E.C. number2.7.1.40
Location of functional site(s)binding site: 70, 73, 106, 295, 296, 328, 464, 482, 489; metal binding: 75, 77, 113, 114, 272, 296; site: 270
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionthyroid hormone binding activity monomer binds 3,3',5-triiodo-L-thyronine (T3)
References for functionParkison C, Ashizawa K, McPhie P, Lin KH, Cheng SY. The monomer of pyruvate kinase, subtype M1, is both a kinase and a cytosolic thyroid hormone binding protein. Biochem Biophys Res Commun. 1991 Aug 30;179(1):668-74. PMID: 1883388
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments