Protein Information

General Information
MoonProt ID254
First appeared in release1.0
Name(s)Band 3 anion exchanger Anion exchange protein 1 Band 3 anion transport protein AE 1 Anion exchanger 1 Solute carrier family 4 member 1 CD_antigen=CD233 Gene Name: SLC4A1
UniProt IDP02730 (B3AT_HUMAN), Reviewed
GO termsGO:0006810 transport GO:0006811 ion transport GO:0006820 anion transport GO:0006821 chloride transport GO:0006873 cellular ion homeostasis GO:0015701 bicarbonate transport GO:0044281 small molecule metabolic process GO:0055085 transmembrane transport GO:1902476 chloride transmembrane transport GO:0003779 actin binding GO:0005215 transporter activity GO:0005452 inorganic anion exchanger activity GO:0005515 protein binding GO:0008022 protein C-terminus binding GO:0008509 anion transmembrane transporter activity GO:0015106 bicarbonate transmembrane transporter activity GO:0015108 chloride transmembrane transporter activity GO:0015301 anion:anion antiporter activity GO:0030506 ankyrin binding GO:0042803 protein homodimerization activity GO:0043495 protein anchor GO:0005886 plasma membrane GO:0005887 integral component of plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane GO:0016323 basolateral plasma membrane GO:0030018 Z disc GO:0030863 cortical cytoskeleton GO:0070062 extracellular vesicular exosome GO:0072562 blood microparticle GO:0005515 protein binding GO:0032947 protein complex scaffold activity
Organisms for which functions have been demonstratedHomo sapiens
Sequence length911
FASTA sequence>sp|P02730|B3AT_HUMAN Band 3 anion transport protein OS=Homo sapiens GN=SLC4A1 PE=1 SV=3 MEELQDDYEDMMEENLEQEEYEDPDIPESQMEEPAAHDTEATATDYHTTSHPGTHKVYVELQELVMDEKNQELRWMEAARWVQLEENLGENGAWGRPHLSHLTFWSLLELRRVFTKGTVLLDLQETSLAGVANQLLDRFIFEDQIRPQDREELLRALLLKHSHAGELEALGGVKPAVLTRSGDPSQPLLPQHSSLETQLFCEQGDGGTEGHSPSGILEKIPPDSEATLVLVGRADFLEQPVLGFVRLQEAAELEAVELPVPIRFLFVLLGPEAPHIDYTQLGRAAATLMSERVFRIDAYMAQSRGELLHSLEGFLDCSLVLPPTDAPSEQALLSLVPVQRELLRRRYQSSPAKPDSSFYKGLDLNGGPDDPLQQTGQLFGGLVRDIRRRYPYYLSDITDAFSPQVLAAVIFIYFAALSPAITFGGLLGEKTRNQMGVSELLISTAVQGILFALLGAQPLLVVGFSGPLLVFEEAFFSFCETNGLEYIVGRVWIGFWLILLVVLVVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFSKLIKIFQDHPLQKTYNYNVLMVPKPQGPLPNTALLSLVLMAGTFFFAMMLRKFKNSSYFPGKLRRVIGDFGVPISILIMVLVDFFIQDTYTQKLSVPDGFKVSNSSARGWVIHPLGLRSEFPIWMMFASALPALLVFILIFLESQITTLIVSKPERKMVKGSGFHLDLLLVVGMGGVAALFGMPWLSATTVRSVTHANALTVMGKASTPGAAAQIQEVKEQRISGLLVAVLVGLSILMEPILSRIPLAVLFGIFLYMGVTSLSGIQLFDRILLLFKPPKYHPDVPYVKRVKTWRMHLFTGIQIICLAVLWVVKSTPASLALPFVLILTVPLRRVLLPLIFRNVELQCLDADDAKATFDEEEGRDEYDEVAMPV
Structure Information
PDB ID1HYN 4KY9 1BZK 1BH7
Quaternary structure
Function 1
Function descriptionBand 3 anion exchanger transports inorganic anions across the plasma membrane in a 1:1 exchange
References for functionLux, Samuel E., et al. "Cloning and characterization of band 3, the human erythrocyte anion-exchange protein (AE1)." Proceedings of the National Academy of Sciences 86.23 (1989): 9089-9093.
E.C. numberN/A
Location of functional site(s)site: 590, 681
Cellular location of functionplasma membrane, transmembrane protein
Comments
Function 2
Function descriptionscaffold protein providing binding sites for glycolytic enzymes involved in regulation of catalytic activity of glycolytic enzymes site of binding is N-terminal cytoplasmic domain of Band 3
References for functionLow PS, Rathinavelu P, Harrison ML. Regulation of glycolysis via reversible enzyme binding to the membrane protein, band 3. J Biol Chem. 1993 Jul 15;268(20):14627-31. PMID: 8325839
E.C. numberN/A
Location of functional site(s)
Cellular location of functionplasma membrane, transmembrane protein
Comments