Protein Information

General Information
MoonProt ID255
First appeared in release1.0
Name(s)Hal3 Phosphopantothenoylcysteine decarboxylase subunit SIS2 Halotolerance protein HAL3 Sit4 suppressor 2 Gene Name:SIS2
UniProt IDP36024 (SIS2_YEAST), Reviewed
GO termsGO:0007346 regulation of mitotic cell cycle GO:0009651 response to salt stress GO:0015937 coenzyme A biosynthetic process GO:0043086 negative regulation of catalytic activity GO:0003824 catalytic activity GO:0004633 phosphopantothenoylcysteine decarboxylase activity GO:0004864 protein phosphatase inhibitor activity GO:0005515 protein binding GO:0004633 phosphopantothenoylcysteine decarboxylase activity GO:0005634 nucleus GO:0005737 cytoplasm GO:0071513 phosphopantothenoylcysteine decarboxylase complex GO:0005515 protein binding
Organisms for which functions have been demonstratedSaccharomyces cerevisiae
Sequence length562
FASTA sequence>sp|P36024|SIS2_YEAST Phosphopantothenoylcysteine decarboxylase subunit SIS2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SIS2 PE=1 SV=1 MTAVASTSGKQDADHNQSIECPRFSRGQKEILLDHEDAKGKDSIINSPVSGRQSISPTLSNATTTTTKSIMNATGTSGAVVSNTPEPGLKRVPAVTFSDLKQQQKQDSLTQLKNDSERTKSPNSNPAPVSNSIPGNHAVIPNHTNTSRTTQLSGSPLVNEMKDYDPKKKDSALKIVDTMKPDKIMATSTPISRENNKVTAKAPTSITLRKEDAQDQANNVSGQINVRSTPEETPVKQSVIPSIIPKRENSKNLDPRLPQDDGKLHVLFGATGSLSVFKIKPMIKKLEEIYGRDRISIQVILTQSATQFFEQRYTKKIIKSSEKLNKMSQYESTPATPVTPTPGQCNMAQVVELPPHIQLWTDQDEWDAWKQRTDPVLHIELRRWADILVVAPLTANTLSKIALGLCDNLLTSVIRAWNPSYPILLAPSMVSSTFNSMMTKKQLQTIKEEMSWVTVFKPSEKVMDINGDIGLGGMMDWNEIVNKIVMKLGGYPKNNEEEDDDEDEEEDDDEEEDTEDKNENNNDDDDDDDDDDDDDDDDDDDDDDDDEDEDEAETPGIIDKHQ
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionSubunit of phosphopantothenoylcysteine decarboxylase (PPCDC) coenzyme A biosynthesis pathway
References for functionFerrando, Alejandro, et al. "Regulation of cation transport in Saccharomyces cerevisiae by the salt tolerance gene HAL3." Molecular and Cellular Biology 15.10 (1995): 5470-5481.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptioninhibitory subunit of protein phosphatase PPZ1
References for functionRuiz A, Gonz?lez A, Mu?oz I, Serrano R, Abrie JA, Strauss E, Ari?o J. Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis. Nat Chem Biol. 2009 Dec;5(12):920-8. doi: 10.1038/nchembio.243. PMID: 19915539
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments