Protein Information

General Information
MoonProt ID256
First appeared in release1.0
Name(s)Phosphopantothenoylcysteine decarboxylase subunit VHS3 Viable in a HAL3 SIT4 background protein 3 Gene Name:VHS3
UniProt IDQ08438 (VHS3_YEAST), Reviewed
GO termsGO:0007049 cell cycle GO:0015937 coenzyme A biosynthetic process GO:0030004 cellular monovalent inorganic cation homeostasis GO:0043086 negative regulation of catalytic activity GO:0003824 catalytic activity GO:0004633 phosphopantothenoylcysteine decarboxylase activity GO:0004864 protein phosphatase inhibitor activity GO:0005515 protein binding GO:0004633 phosphopantothenoylcysteine decarboxylase activity GO:0071513 phosphopantothenoylcysteine decarboxylase complex GO: 0005515 protein binding
Organisms for which functions have been demonstratedSaccharomyces cerevisiae
Sequence length674
FASTA sequence>sp|Q08438|VHS3_YEAST Phosphopantothenoylcysteine decarboxylase subunit VHS3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VHS3 PE=1 SV=1 MTNKSSLKNNRKGVASNTLSGAEQANIGSSAMPDTNSTGPFSSVSSLDTPVVRKSTSPTGSQTKSIMNASGTSGAVVSNTPEPGLKRIPTVTFSDPKLGSLRSDVEQTPPNQVARQSSEKKATSVHIAAEGANQGRNLKDINTKVPKDGEASASSFSTPTSILSNADMGNNISSLLAKKLSFTGGTDSILNSDNSSDSPRKEHPHFYVEDPLHTPSVRSRSNSTSPRPSVVVNTFNPINIEREGSISKTGEPTLLESVLEEAMSPNAVSNPLKRENIMTNMDPRLPQDDGKLHVLFGATGSLSVFKLKHMIRKLEEIYGRDKICIQVILTNSATKFFAMKYMRKNKKQHNSIDTSFNSTNSNAGNITGNKKKVASLEKFSIQKTSSNSAASQTNNKQEEEKQMASTTGFPSTLGGSRTYSNSSNVVSQHPQIELPAHIQFWTDQDEWDVWRQRTDPVLHIELRRWADILVVAPLTANTLAKIALGLCDNLLTSVIRAWNPTFPIFLAPSMGSGTFNSIMTKKHFRIIQEEMPWVTVFKPSEKVMGINGDIGLSGMMDANEIVGKIVVKLGGYPDVSAGKEEEEDEDNDEEDDNKKNDTGGKDEDNDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDEDDEDEDEDDEGKKKEDKGGLQRS
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionSubunit of phosphopantothenoylcysteine decarboxylase (PPCDC) coenzyme A biosynthesis pathway
References for functionRuiz, Amparo, et al. "Functional Characterization of the Saccharomyces cerevisiae VHS3 Gene A Regulatory Subunit of The Ppz1 Protein Phosphatase With Novel, Phosphatase-Unrelated Functions." Journal of Biological Chemistry 279.33 (2004): 34421-34430.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptioninhibitory subunit of protein phosphatase PPZ1
References for functionRuiz A, Gonz?lez A, Mu?oz I, Serrano R, Abrie JA, Strauss E, Ari?o J. Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis. Nat Chem Biol. 2009 Dec;5(12):920-8. doi: 10.1038/nchembio.243. PMID: 19915539
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments