Protein Information

General Information
MoonProt ID257
First appeared in release1.0
Name(s)Intron-associated endonuclease 1 I-TevI IRF protein Gene Name:ITEVIR
UniProt IDP13299 (TEV1_BPT4), Reviewed
GO termsGO:0006314 intron homing GO:0090305 nucleic acid phosphodiester bond hydrolysis GO:0004518 nuclease activity GO:0005515 protein binding GO:0004519 endonuclease activity GO:0016787 hydrolase activity GO:0006351 transcription, DNA-templated
Organisms for which functions have been demonstratedbacteriophage T4
Sequence length245
FASTA sequence>sp|P13299|TEV1_BPT4 Intron-associated endonuclease 1 OS=Enterobacteria phage T4 GN=ITEVIR PE=1 SV=2 MKSGIYQIKNTLNNKVYVGSAKDFEKRWKRHFKDLEKGCHSSIKLQRSFNKHGNVFECSILEEIPYEKDLIIERENFWIKELNSKINGYNIADATFGDTCSTHPLKEEIIKKRSETVKAKMLKLGPDGRKALYSKPGSKNGRWNPETHKFCKCGVRIQTSAYTCSKCRNRSGENNSFFNHKHSDITKSKISEKMKGKKPSNIKKISCDGVIFDCAADAARHFKISSGLVTYRVKSDKWNWFYINA
Structure Information
PDB ID1I3J 1MK0 1LN0
Quaternary structure
Function 1
Function descriptionhoming endonuclease, enzyme intron-encoded binds cognate intronless alleles
References for functionWest DK, Changchien LM, Maley GF, Maley F. Evidence that the intron open reading frame of the phage T4 td gene encodes a specific endonuclease. J Biol Chem. 1989 Jun 25;264(18):10343-6. PMID: 2543665
E.C. number3.1.-.-
Location of functional site(s)
Cellular location of functioncytoplasm, bound to DNA
Comments
Function 2
Function descriptiontranscriptional autorepressor
References for functionEdgell DR, Derbyshire V, Van Roey, LaBonne S, Stanger MJ, Li Z, Boyd TM, Shub DA, Belfort M. Intron-encoded homing endonuclease I-TevI also functions as a transcriptional autorepressor. Nat Struct Mol Biol. 2004 Oct;11(10):936-44. PMID: 15361856
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm, bound to DNA
Comments