Protein Information

General Information
MoonProt ID26
First appeared in release1.0
Name(s)Enolase 2-phospho-D-glycerate hydro-lyase 2-phosphoglycerate dehydratase Gene Name: eno
UniProt IDB7GTK2 (ENO_BIFLS), Reviewed
GO termsGO:0006096 glycolysis GO:0000287 magnesium ion binding GO:0004634 phosphopyruvate hydratase activity GO:0016829 lyase activity GO:0046872 metal ion binding GO:0000015 phosphopyruvate hydratase complex GO:0005576 extracellular region GO:0005737 cytoplasm GO:0009986 cell surface GO: 0005515 protein binding
Organisms for which functions have been demonstratedBifidobacterium (B. longum, B. bifidum, B. breve and B. lactis) - health-promoting member of the human intestinal microbiota
Sequence length432
FASTA sequence>gi|384199907|ref|YP_005585650.1| enolase [Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222] MAVIESVYARQILDSRGNPTVEVYLETEDGAQGKGLVPSGASTGEAEAWERRDGDKSVYGGKGVLNAVKAVNEVIAPKVIGMDAADQRALDDLMIELDGTPNKGKLGANAILGVSLAALYASAESAGLPLYRYIGGTNGHILPVPNMNIMNGGAHADFATDIQEYMISPYGFDTYSEALRAGVEVYHTLKNVLKKEGLNTGLGDEGGFAPKMKSNEDSLKYIMDAISAAGYEPGKQIGICLDVASSEFYNKETGKYRFDGEERDSAYMLDYYENLINEYPIVSIEDPFNEEGWEDWAAITARLGDRLQFVGDDLLVTNPARLQKAIDLGAANSLLVKLNQIGSVTETLDAIELATANGYTSMVSHRSGETPDTTISDLAVAKNTRQIKTGAPARGERVAKYNRLLEIEEELGSTAQYAGYTAFKACKKYLAK
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionenolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysis
References for functionCandela M, Biagi E, Centanni M, Turroni S, Vici M, Musiani F, Vitali B, Bergmann S, Hammerschmidt S, Brigidi P. Bifidobacterial enolase, a cell surface receptor for human plasminogen involved in the interaction with the host. Microbiology. 2009 Oct;155(Pt 10):3294-303.doi: 10.1099/mic.0.028795-0. Epub 2009 Jul 2. PMID: 19574304
E.C. numberEC=4.2.1.11
Location of functional site(s)Active site:205,337 Binding site:164,388,285,155,312,337 Metal binding site:242,312,285
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionplasminogen binding (binds human plasminogen)
References for functionCandela M, Biagi E, Centanni M, Turroni S, Vici M, Musiani F, Vitali B, Bergmann S, Hammerschmidt S, Brigidi P. Bifidobacterial enolase, a cell surface receptor for human plasminogen involved in the interaction with the host. Microbiology. 2009 Oct;155(Pt 10): 3294-303.doi: 10.1099/mic.0.028795-0. Epub 2009 Jul 2. PMID: 19574304
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface, cell wall
Comments