Protein Information

General Information
MoonProt ID267
First appeared in release1.0
Name(s)Vacuolar protein-sorting-associated protein 36 ESCRT-II complex subunit VPS36 Gene Name: Vps36
UniProt IDQ9VU87 (VPS36_DROME), Reviewed
GO termsGO:0006810 transport GO:0007224 smoothened signaling pathway GO:0008283 cell proliferation GO:0008593 regulation of Notch signaling pathway GO:0015031 protein transport GO:0042981 regulation of apoptotic process GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0051028 mRNA transport GO:0003723 RNA binding GO:0003730 mRNA 3'-UTR binding GO:0032266 phosphatidylinositol-3-phosphate binding GO:0043130 ubiquitin binding GO:0000814 ESCRT II complex GO:0005737 cytoplasm GO:0005768 endosome GO:0036452 ESCRT complex GO:0003729
Organisms for which functions have been demonstratedDrosphila melanogaster
Sequence length399
FASTA sequence>sp|Q9VU87|VPS36_DROME Vacuolar protein-sorting-associated protein 36 OS=Drosophila melanogaster GN=Vps36 PE=2 SV=2 MNRFAYVEARLSPNESFVSRDNRVKIYDGDQKTDFEDGEVVLTTHRLFWGRPGEIARAAVTLCLPLSYVISVSEETTASNFFGRKTRIIMHLHPPTSDKGPGPLDTSRATHIKLSGKNGLSVEFHSALRETLNARVWEILLTSEIIINGVASSPTLEPANDRLARIQKRTGIGGIERHLEAKAKATDENIALAFQDLSVLMAMAKDMVGVSKTISSKIRKQKGEISDDETVRFKSYLMSLGIDDPVTRDNFTSNSAYFSSLARQICEMLLDPIEEQGGMMSLADVYCRVNRARGLELLSPEDLLHACEQLSGPIRLRSFPSGARVLQLESHDDALIAVDTLEKVEAAESLAVEELAKQLGISLLLAKERLLVAERLGKVCRDESVEGLRFYPNLLLGRD
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionComponent of the ESCRT-II complex (ensodomal sorting complex required for transport II) complex needed for sorting ubiquitinated endosomal proteins into multivesicular bodies important for transport of transmembrane proteins to the lysosome for degradation
References for functionHerz, Hans-Martin, et al. "Common and distinct genetic properties of ESCRT-II components in Drosophila." PLoS One 4.1 (2009): e4165.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm, endosomal membrane
Comments
Function 2
Function descriptionmRNA binding binds to the localization element in the 3' untranslated region (UTR) of bicoid mRNA functions in localizing bicoid mRNA to the anterior of the Drosophila egg
References for functionIrion U, St Johnston. bicoid RNA localization requires specific binding of an endosomal sorting complex. Nature. 2007 Feb 1. PMID: 17268469
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments