Protein Information

General Information
MoonProt ID270
First appeared in release1.0
Name(s)ribosomal protein S14 Gene Name:RPS14
UniProt IDP62263 (RS14_HUMAN), Reviewed
GO termsGO:0000028 ribosomal small subunit assembly GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0006412 translation GO:0006413 translational initiation GO:0006414 translational elongation GO:0006415 translational termination GO:0006417 regulation of translation GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0010467 gene expression GO:0016032 viral process GO:0016070 RNA metabolic process GO:0016071 mRNA metabolic process GO:0019058 viral life cycle GO:0019083 viral transcription GO:0030218 erythrocyte differentiation GO:0030490 maturation of SSU-rRNA GO:0044267 cellular protein metabolic process GO:0003723 RNA binding GO:0003735 structural constituent of ribosome GO:0044822 poly(A) RNA binding GO:0045182 translation regulator activity GO:0048027 mRNA 5'-UTR binding GO:0005730 nucleolus GO:0005739 mitochondrion GO:0005829 cytosol GO:0005840 ribosome GO:0022627 cytosolic small ribosomal subunit GO:0030529 ribonucleoprotein complex GO:0070062 extracellular vesicular exosome GO:0003729 mRNA binding GO:0009299 mRNA transcription
Organisms for which functions have been demonstratedHomo sapiens
Sequence length
FASTA sequence>sp|P62263|RS14_HUMAN 40S ribosomal protein S14 OS=Homo sapiens GN=RPS14 PE=1 SV=3 MAPRKGKEKKEEQVISLGPQVAEGENVFGVCHIFASFNDTFVHVTDLSGKETICRVTGGMKVKADRDESSPYAAMLAAQDVAQRCKELGITALHIKLRATGGNRTKTPGPGAQSALRALARSGMKIGRIEDVTPIPSDSTRRKGGRRGRRL
Structure Information
PDB ID3J3A, 4KZX, 4KZY, 4KZZ, 4KZQ
Quaternary structure
Function 1
Function descriptionribosomal protein
References for functionChen, I-Tsuen, et al. "Homologous ribosomal proteins in bacteria, yeast, and humans." Proceedings of the National Academy of Sciences 83.18 (1986): 6907-6911.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm, part of the ribosome
Comments
Function 2
Function descriptioninhibits S14 mRNA transcription negative effector of transcription of its own RNA
References for functionTasheva ES, Roufa DJ. Regulation of human RPS14 transcription by intronic antisense RNAs and ribosomal protein S14. Genes Dev. 1995 Feb 1;9(3):304-16. PMID: 7867928
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments