Protein Information

General Information
MoonProt ID271
First appeared in release1.0
Name(s)Signal transducer and activator of transcription 3 Acute-phase response factor Gene Name:Stat3
UniProt IDP42227 (STAT3_MOUSE), Reviewed
GO termsGO:0001659 temperature homeostasis GO:0001754 eye photoreceptor cell differentiation GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006606 protein import into nucleus GO:0006953 acute-phase response GO:0007165 signal transduction GO:0007259 JAK-STAT cascade GO:0008283 cell proliferation GO:0008285 negative regulation of cell proliferation GO:0010033 response to organic substance GO:0014070 response to organic cyclic compound GO:0016310 phosphorylation GO:0019221 cytokine-mediated signaling pathway GO:0019827 stem cell maintenance GO:0019953 sexual reproduction GO:0030522 intracellular receptor signaling pathway GO:0032355 response to estradiol GO:0032870 cellular response to hormone stimulus GO:0034097 response to cytokine GO:0040014 regulation of multicellular organism growth GO:0042493 response to drug GO:0042593 glucose homeostasis GO:0042755 eating behavior GO:0043434 response to peptide hormone GO:0045471 response to ethanol GO:0045747 positive regulation of Notch signaling pathway GO:0045820 negative regulation of glycolytic process GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048708 astrocyte differentiation GO:0060019 radial glial cell differentiation GO:0060396 growth hormone receptor signaling pathway GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060548 negative regulation of cell death GO:0070102 interleukin-6-mediated signaling pathway GO:2001223 negative regulation of neuron migration GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0001103 RNA polymerase II repressing transcription factor binding GO:0003677 DNA binding GO:0003700 sequence-specific DNA binding transcription factor activity GO:0004871 signal transducer activity GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0005509 calcium ion binding GO:0005515 protein binding GO:0008134 transcription factor binding GO:0019901 protein kinase binding GO:0019903 protein phosphatase binding GO:0031730 CCR5 chemokine receptor binding GO:0035259 glucocorticoid receptor binding GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding GO:0046983 protein dimerization activity GO:0005634 nucleus GO:0005654 nucleoplasm GO:0005737 cytoplasm GO:0005829 cytosol GO:0005886 plasma membrane GO:0005746 mitochondrial respiratory chain
Organisms for which functions have been demonstratedMus musculus
Sequence length770
FASTA sequence>sp|P42227|STAT3_MOUSE Signal transducer and activator of transcription 3 OS=Mus musculus GN=Stat3 PE=1 SV=2 MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMDLTSECATSPM
Structure Information
PDB ID4E68, 1BG1, 2CWG
Quaternary structure
Function 1
Function descriptiontranscription factor, binds DNA in response to cytokines (IL-6, and other growth factors) binds promoters containing IL-6 responsive elements
References for functionZhong, Zhong, Zilong Wen, and James E. Darnell Jr. "Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6." Science264.5155 (1994): 95-99.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm, nucleus
Comments
Function 2
Function descriptionmodulates the activities of complexes I and II of the electron transport chain (ETC) in the mitochondria
References for functionWegrzyn J, Potla R, Chwae YJ, Sepuri NB, Zhang Q, Koeck T, Derecka M, Szczepanek K, Szelag M, Gornicka A, Moh A, Moghaddas S, Chen Q, Bobbili S, Cichy J, Dulak J, Baker DP, Wolfman A, Stuehr D, Hassan MO, Fu XY, Avadhani N, Drake JI, Fawcett P, Lesnefsky EJ, Larner AC. Function of mitochondrial Stat3 in cellular respiration. Science. 2009 Feb 6;323(5915):793-7. doi: 10.1126/science.1164551. PMID: 19131594
E.C. numberN/A
Location of functional site(s)
Cellular location of functionmitochondrion
Comments