Protein Information

General Information
MoonProt ID273
First appeared in release1.0
Name(s)Fructose-bisphosphate aldolase
UniProt IDP49577
GO termsGO:0006096 glycolytic process GO:0003824 catalytic activity GO:0004332 fructose-bisphosphate aldolase activity GO:0016829 lyase activity GO:0005515 protein binding GO:0003779 actin binding GO:0015629 Jactin cytoskeleton
Organisms for which functions have been demonstratedPlasmodium berghei
Sequence length358 aa
FASTA sequence>sp|P49577|ALF2_PLABA Fructose-bisphosphate aldolase 2 OS=Plasmodium berghei (strain Anka) GN=ALDO2 PE=3 SV=1 MKLPKEDAQELAETAKKLVAAGKGILAADESTQTIKKRFDNIKIENTVQNRASYRDLLFGTKGLGKFISGAILFEETLFQKNEAGVPLVNLLHDEGIIPGIKVDKGLVSIPCTDDEKSTQGLDGLAERCKEYYKAGARFAKWRAVLVIDPAKGKPTDLSIQEVSWGLARYASICQQNKLVPIVEPEILADGAHTIEVCATVTQKVLASVFKALHDNGVLLEGASLKPNMVTAGYDCTEKTKTDDIGFFTVRTLRRTVPPALPGVAFLSGGQSEEDASINLNSINVLGPHPWALTFSYGRALQASVLNTWQGKKENVAKARRVLLQRAEANSLATYGKYKGGAGGSTAGASLYEKKYVY
Structure Information
PDB ID2EPH, 2PC4, 1A5C
Quaternary structure
Function 1
Function descriptionFructose-bisphosphate aldolase, enzyme D-fructose 1,6-bisphosphate => dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate Carbohydrate degradation, glycolysis
References for functionCerta, Ulrich. "Regular initiation of translation of Plasmodium berghei aldolase-2 after pre-mRNA splicing." Molecular and biochemical parasitology 63.2 (1994): 291-297.
E.C. number4.1.2.13
Location of functional site(s)binding site: 51, 141; active site: 184, 226; site: 358
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionattaches actin filaments to TRAP proteins (transmembrane adhesive proteins of the thrombospondin-related anonymous protein) and transduces the motor force across the surface of the plasmodium
References for functionBosch J, Buscaglia CA, Krumm B, Ingason BP, Lucas R, Roach C, Cardozo T, Nussenzweig V, Hol WG. Aldolase provides an unusual binding site for thrombospondin-related anonymous protein in the invasion machinery of the malaria parasite. Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7015-20. PMID: 17426153
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm, near plasma membrane
Comments