Protein Information

General Information
MoonProt ID274
First appeared in release1.0
Name(s)Fructose-bisphosphate aldolase
UniProt IDS8GE25 (S8GE25_TOXGO), Unreviewed
GO termsGO:0006096 glycolytic process GO:0003824 catalytic activity GO:0004332 fructose-bisphosphate aldolase activity GO:0016829 lyase activity GO:0005515 protein binding GO:0003779 actin binding GO:0015629 Jactin cytoskeleton
Organisms for which functions have been demonstratedToxoplasma gondii
Sequence length433
FASTA sequence>tr|S8GE25|S8GE25_TOXGO Fructose-bisphosphate aldolase OS=Toxoplasma gondii ME49 GN=TGME49_236040 PE=3 SV=1 MLCIVERIAMPTRGVNPSAANGKLPPRTRSATGCRVYIHPMVKFISLLFAVFYARFFLLFCVRIQSTFPTMSGYGLPISQEVAKELAENARKIAAPGKGILAADESTGTIKKRFDSIGVENTEANRAFYRDLLFSTKGLGQYISGAILFEETLYQKSPSGVPMVDLLKAEGIIPGIKVDKGLETLPLTDDEKATMGLDGLSERCKKYYEAGARFAKWRAVLSIDPAKGKPTNLSITEVAHGLARYAAICQANRLVPIVEPEILTDGSHDITVCAEVTERVLAAVFKALNDHHVLLEGALLKPNMVTHGSDCPKPASHEEIAFYTVRSLKRTVPPALPGVMFLSGGQSEEDASLNLNEMNKMGPHPFQLSFSYGRALQASCLKAWKGVPENKAKAQQVLMERARANGEAQLGKYGGGAGGAAAASSLFEKRYVY
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionFructose-bisphosphate aldolase, enzyme D-fructose 1,6-bisphosphate => dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate Carbohydrate degradation, glycolysis
References for functionBoucher, Lauren E., and J├╝rgen Bosch. "Structure of Toxoplasma gondii fructose-1, 6-bisphosphate aldolase." Acta Crystallographica Section F: Structural Biology Communications70.9 (2014): 1186-1192.
E.C. number4.1.2.13
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionprotein-protein interactions couples actin cytoskeleton filaments in the cytoplasm to the surface adhesin microneme protein 2 (MIC2)
References for functionStarnes GL, Coincon M, Sygusch J, Sibley LD. Aldolase is essential for energy production and bridging adhesin-actin cytoskeletal interactions during parasite invasion of host cells. Cell Host Microbe. 2009 Apr 23;5(4):353-64. doi: 10.1016/j.chom.2009.03.005. PMID: 19380114
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm, near plasma membrane
Comments