Protein Information

General Information
MoonProt ID28
First appeared in release1.0
Name(s)enolase Enolase 1 2-phospho-D-glycerate hydro-lyase 2-phosphoglycerate dehydratase Gene Name: ENO1
UniProt IDP30575 (ENO1_CANAL), Reviewed
GO termsGO:0006094 gluconeogenesis GO:0006096 glycolysis GO:0030447 filamentous growth GO:0036180 filamentous growth of a population of unicellular organisms in response to biotic stimulus GO:0044409 entry into host GO:0044416 induction by symbiont of host defense response GO:0000287 magnesium ion binding GO:0004634 phosphopyruvate hydratase activity GO:0005515 protein binding GO:0016829 lyase activity GO:0030985 high molecular weight kininogen binding GO:0046872 metal ion binding GO:0000015 phosphopyruvate hydratase complex GO:0005576 extracellular region GO:0005622 intracellular GO:0005634 nucleus GO:0005737 cytoplasm GO:0005829 cytosol GO:0005886 plasma membrane GO:0009277 fungal-type cell wall GO:0009986 cell surface GO:0016020 membrane GO:0030445 yeast-form cell wall GO:0030446 hyphal cell wall GO: 0005515 protein binding
Organisms for which functions have been demonstratedCandida albicans
Sequence length440
FASTA sequence>sp|P30575|ENO1_CANAL Enolase 1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ENO1 PE=1 SV=1 MSYATKIHARYVYDSRGNPTVEVDFTTDKGLFRSIVPSGASTGVHEALELRDGDKSKWLGKGVLKAVANVNDIIAPALIKAKIDVVDQAKIDEFLLSLDGTPNKSKLGANAILGVSLAAANAAAAAQGIPLYKHIANISNAKKGKFVLPVPFQNVLNGGSHAGGALAFQEFMIAPTGVSTFSEALRIGSEVYHNLKSLTKKKYGQSAGNVGDEGGVAPDIKTPKEALDLIMDAIDKAGYKGKVGIAMDVASSEFYKDGKYDLDFKNPESDPSKWLSGPQLADLYEQLISEYPIVSIEDPFAEDDWDAWVHFFERVGDKIQIVGDDLTVTNPTRIKTAIEKKAANALLLKVNQIGTLTESIQAANDSYAAGWGVMVSHRSGETEDTFIADLSVGLRSGQIKTGAPARSERLAKLNQILRIEEELGSEAIYAGKDFQKASQL
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionenolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Carbohydrate degradation, glycolysis
References for function
E.C. number4.2.1.11
Location of functional site(s)Active site:213,349 Binding site:170,297,161,400,324 Metal binding site:248,297,324
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionplasminogen binding
References for functionJong AY, Chen SH, Stins MF, Kim KS, Tuan TL, Huang SH. Binding of Candida albicans enolase to plasmin(ogen) results in enhanced invasion of human brain microvascular endothelial cells. J Med Microbiol. 2003 Aug;52(Pt 8):615-22. PMID: 12867553
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments