Protein Information

General Information
MoonProt ID282
First appeared in release1.0
Name(s)P0 ribosomal protein 60S acidic ribosomal protein P0 Apurinic-apyrimidinic endonuclease DNA-(apurinic or apyrimidinic site) lyase Gene Name:RpLP0
UniProt IDP19889 (RLA0_DROME), Reviewed
GO termsGO:0000737 DNA catabolic process, endonucleolytic GO:0006281 DNA repair GO:0006414 translational elongation GO:0006974 cellular response to DNA damage stimulus GO:0042254 ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity GO:0016829 lyase activity GO:0005622 intracellular GO:0005634 nucleus GO:0005737 cytoplasm GO:0005840 ribosome GO:0030529 ribonucleoprotein complex GO:0052720 apurinic/apyrimidinic endodeoxyribonuclease activity
Organisms for which functions have been demonstratedDrosophila melanogaster
Sequence length317
FASTA sequence>sp|P19889|RLA0_DROME 60S acidic ribosomal protein P0 OS=Drosophila melanogaster GN=RpLP0 PE=1 SV=1 MVRENKAAWKAQYFIKVVELFDEFPKCFIVGADNVGSKQMQNIRTSLRGLAVVLMGKNTMMRKAIRGHLENNPQLEKLLPHIKGNVGFVFTKGDLAEVRDKLLESKVRAPARPGAIAPLHVIIPAQNTGLGPEKTSFFQALSIPTKISKGTIEIINDVPILKPGDKVGASEATLLNMLNISPFSYGLIVNQVYDSGSIFSPEILDIKPEDLRAKFQQGVANLAAVCLSVGYPTIASAPHSIANGFKNLLAIAATTEVEFKEATTIKEYIKDPSKFAAAASASAAPAAGGATEKKEEAKKPESESEEEDDDMGFGLFD
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionP0 ribosomal protein part of the 60S subunit
References for functionKelley, M. R., et al. "Antibody to a human DNA repair protein allows for cloning of a Drosophila cDNA that encodes an apurinic endonuclease." Molecular and cellular biology 9.3 (1989): 965-973.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm, part of the ribosome
Comments
Function 2
Function descriptionApurinic-apyrimidinic endonuclease, enzyme functions in DNA repair act on AP DNA, cleaves 5' of a baseless site
References for functionYacoub A, Kelley MR, Deutsch WA. Drosophila ribosomal protein PO contains apurinic/apyrimidinic endonuclease activity. Nucleic Acids Res. 1996 Nov 1;24(21):4298-303. PMID: 8932386
E.C. number4.2.99.18
Location of functional site(s)
Cellular location of functionnucleus
Comments