Protein Information

General Information
MoonProt ID29
First appeared in release1.0
Name(s)Enolase 2-phospho-D-glycerate hydro-lyase 2-phosphoglycerate dehydratase Gene Name: eno
UniProt IDQ5K117 (Q5K117_9LACO), Unreviewed
GO termsGO:0006096 glycolysis GO:0000287 magnesium ion binding GO:0004634 phosphopyruvate hydratase activity GO:0016829 lyase activity GO:0046872 metal ion binding GO:0000015 phosphopyruvate hydratase complex GO:0005576 extracellular region GO:0005737 cytoplasm GO:0009986 cell surface GO: 0098631 cell adhesion mediator activity GO: 0005515 protein binding
Organisms for which functions have been demonstratedLactobacillus crispatus
Sequence length428
FASTA sequence>gi|557948974|gb|EST03466.1| enolase [Lactobacillus crispatus EM-LC1] MLKSVIENVHALEIFDSRGNPTVEVHVTLSNGVVGKAEVPSGASTGENEAVELRDGGSRLGGKGVSKAVNNVNTEINDALKGMDPYNQPKIDKTMIDLDGTPNKGRLGANAILGVSMAVAVAAANDAHLPLYRYLGGTDLEMPQTFHNVINGGEHADNGIDIQEFMITPVAKTSFRDGFEKIVNVYHTLKKVLEDMGYETGLGDEGGFAPNMKNSEEALKALHESIIKAGYKPGEDIAIACDCAASYFYNKDDHKYHLEGKVLTDEELADYYDKLLDEFPELISMEDPYDENDVDGMVKFTKSHKDRIQIVLDDFICTNPALLTKAIKEGAGNASLIKLNQIGTVTETLETIRLSRKNGYNTMISHRSGETGDTFIADLAVAVNGGQLKTGAPARSERVEKYNRLLEIEEELGDGERLAFFPDDVDHD
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionEnolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O. Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysis;
References for functionAntikainen J, Kuparinen V, L?hteenm?ki K, Korhonen TK. Enolases from Gram-positive bacterial pathogens and commensal lactobacilli share functional similarity in virulence-associated traits. FEMS Immunol Med Microbiol. 2007 Dec;51(3):526-34. Epub 2007 Sep 24. PMID: 17892475
E.C. number4.2.1.11
Location of functional site(s)Active site:205,338 Binding site:164,313,338,286,389,155 Metal binding site:313,242,286
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionbinds plasminogen and laminin
References for functionAntikainen J, Kuparinen V, L?hteenm?ki K, Korhonen TK. Enolases from Gram-positive bacterial pathogens and commensal lactobacilli share functional similarity in virulence-associated traits. FEMS Immunol Med Microbiol. 2007 Dec;51(3):526-34. Epub 2007 Sep 24. PMID: 17892475
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments