Protein Information

General Information
MoonProt ID290
First appeared in release1.0
Name(s)Mitochondrial ribonuclease P protein 1 Mitochondrial RNase P protein 1 HBV pre-S2 trans-regulated protein 2 RNA (guanine-9-)-methyltransferase domain-containing protein 1 Renal carcinoma antigen NY-REN-49 tRNA methyltransferase 10 homolog C Gene Name:TRMT10C
UniProt IDQ7L0Y3 (MRRP1_HUMAN), Reviewed
GO termsGO:0000964 mitochondrial RNA 5'-end processing GO:0008033 tRNA processing GO:0032259 methylation GO:0005515 protein binding GO:0008168 methyltransferase activity GO:0016740 transferase activity GO:0044822 poly(A) RNA binding GO:0005739 mitochondrion GO:0042645 mitochondrial nucleoid GO:0008175 tRNA methyltransferase activity
Organisms for which functions have been demonstratedHomo sapiens
Sequence length
FASTA sequence>sp|Q7L0Y3|MRRP1_HUMAN Mitochondrial ribonuclease P protein 1 OS=Homo sapiens GN=TRMT10C PE=1 SV=2 MAAFLKMSVSVNFFRPFTRFLVPFTLHRKRNNLTILQRYMSSKIPAVTYPKNESTPPSEELELDKWKTTMKSSVQEECVSTISSSKDEDPLAATREFIEMWRLLGREVPEHITEEELKTLMECVSNTAKKKYLKYLYTKEKVKKARQIKKEMKAAAREEAKNIKLLETTEEDKQKNFLFLRLWDRNMDIAMGWKGAQAMQFGQPLVFDMAYENYMKRKELQNTVSQLLESEGWNRRNVDPFHIYFCNLKIDGALHRELVKRYQEKWDKLLLTSTEKSHVDLFPKDSIIYLTADSPNVMTTFRHDKVYVIGSFVDKSMQPGTSLAKAKRLNLATECLPLDKYLQWEIGNKNLTLDQMIRILLCLKNNGNWQEALQFVPKRKHTGFLEISQHSQEFINRLKKAKT
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionMitochondrial ribonuclease P protein 1, noncatalytic subunit cleaves tRNA molecules in their 5'-ends subunit of ribonuclease P, not catalytic subunit for this function required for ribonuclease P activity
References for functionVilardo E1, Nachbagauer C, Buzet A, Taschner A, Holzmann J, Rossmanith W. A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase--extensive moonlighting in mitochondrial tRNA biogenesis. Nucleic Acids Res. 2012 Dec;40(22):11583-93. doi: 10.1093/nar/gks910. PMID: 23042678
E.C. numberN/A
Location of functional site(s)
Cellular location of functionmitochondrion
Comments
Function 2
Function descriptiontRNA methyltransferase, enzyme
References for functionVilardo E, Nachbagauer C, Buzet A, Taschner A, Holzmann J, Rossmanith W. A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase--extensive moonlighting in mitochondrial tRNA biogenesis. Nucleic Acids Res. 2012 Dec;40(22):11583-93. doi: 10.1093/nar/gks910. PMID: 23042678
E.C. number
Location of functional site(s)
Cellular location of functionmitochondrion
Comments