Protein Information

General Information
MoonProt ID291
First appeared in release1.0
Name(s)Zuotin DnaJ-related protein ZUO1 J protein ZUO1 Heat shock protein 40 homolog ZUO1 Ribosome-associated complex subunit ZUO1 Gene Name: ZUO1
UniProt IDP32527 (ZUO1_YEAST), Reviewed
GO termsGO:0000054 ribosomal subunit export from nucleus GO:0006364 rRNA processing GO:0006450 regulation of translational fidelity GO:0006452 translational frameshifting GO:0006457 protein folding GO:0003677 DNA binding GO:0005515 protein binding GO:0051082 unfolded protein binding GO:0005730 nucleolus GO:0005737 cytoplasm GO:0008134 transcription factor binding
Organisms for which functions have been demonstratedSaccharomyces cerevisiae
Sequence length433
FASTA sequence>sp|P32527|ZUO1_YEAST Zuotin OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ZUO1 PE=1 SV=1 MFSLPTLTSDITVEVNSSATKTPFVRRPVEPVGKFFLQHAQRTLRNHTWSEFERIEAEKNVKTVDESNVDPDELLFDTELADEDLLTHDARDWKTADLYAAMGLSKLRFRATESQIIKAHRKQVVKYHPDKQSAAGGSLDQDGFFKIIQKAFETLTDSNKRAQYDSCDFVADVPPPKKGTDYDFYEAWGPVFEAEARFSKKTPIPSLGNKDSSKKEVEQFYAFWHRFDSWRTFEFLDEDVPDDSSNRDHKRYIERKNKAARDKKKTADNARLVKLVERAVSEDPRIKMFKEEEKKEKERRKWEREAGARAEAEAKAKAEAEAKAKAESEAKANASAKADKKKAKEAAKAAKKKNKRAIRNSAKEADYFGDADKATTIDEQVGLIVDSLNDEELVSTADKIKANAAGAKEVLKESAKTIVDSGKLPSSLLSYFV
Structure Information
PDB ID2LWX
Quaternary structure
Function 1
Function descriptioncomponent of a chaperone complex component of the ribosome-associated complex (RAC) that helps in folding of nascent polypeptide chains
References for functionZhang, Shuguang, et al. "Zuotin, a putative Z-DNA binding protein in Saccharomyces cerevisiae." The EMBO journal 11.10 (1992): 3787.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionactivator of a transcription factor activates Pdr1 transcription factor
References for functionDucett JK, Peterson FC, Hoover LA, Prunuske AJ, Volkman BF, Craig EA. Unfolding of the C-terminal domain of the J-protein Zuo1 releases autoinhibition and activates Pdr1-dependent transcription. J Mol Biol. 2013 Jan 9;425(1):19-31. doi: 10.1016/j.jmb.2012.09.020. PMID: 23036859
E.C. numberN/A
Location of functional site(s)
Cellular location of functionnucleus
Comments