Protein Information

General Information
MoonProt ID30
First appeared in release1.0
Name(s)Enolase Enolase 1 2-phospho-D-glycerate hydro-lyase 1 2-phosphoglycerate dehydratase 1 Gene Name: eno1
UniProt IDQ74K78 (ENO1_LACJO), Reviewed
GO termsGO:0006096 glycolysis GO:0000287 magnesium ion binding GO:0004634 phosphopyruvate hydratase activity GO:0016829 lyase activity GO:0046872 metal ion binding GO:0000015 phosphopyruvate hydratase complex GO:0005576 extracellular region GO:0005737 cytoplasm GO:0009986 cell surface GO: 0098631 cell adhesion mediator activity GO: 0005515 protein binding
Organisms for which functions have been demonstratedLactobacillus johnsonii
Sequence length432
FASTA sequence>sp|Q74K78|ENO1_LACJO Enolase 1 OS=Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533) GN=eno1 PE=3 SV=1 MSVITDIHAREVLDSRGNPTVEAEVYTELGGFGRAIVPSGASTGEHEAVELRDGDKSRFLGQGVLTAVENVNGEIAKAVIGLDVTDQRLIDQTMIDLDGTPNKGRLGANAMLAVSLASARAAADELGLPLYEYLGGPNAHVLPTPMMNVINGGKHADNNVDIQEFMIMPVGAKSLHEAVRMGAETFHTLKSLLQERGESTAVGDEGGFAPNLKNNEEPFEILVEAIQRAGYKPGQDISIAFDCAASEFYNKDTKKYVTVADGREYTAEEWTSLMEDIVDKYPVISIEDPLDENDWEGWKVFTERLGDKVQIVGDDLFVTNTNYLEKGIKMGVANSILIKLNQIGTLTETFEAIEMAKEAGYTAVVSHRSGETEDTTIADLVVATNAGQIKTGSMSRTDRIAKYNQLMRIEEALGSTAQYKGIHSFYNLHKQF
Structure Information
PDB ID
Quaternary structure
Function 1
Function description2-phospho-D-glycerate => phosphoenolpyruvate + H2O. Pathway Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysis
References for functionAntikainen J, Kuparinen V, L?hteenm?ki K, Korhonen TK. Enolases from Gram-positive bacterial pathogens and commensal lactobacilli share functional similarity in virulence-associated traits. FEMS Immunol Med Microbiol. 2007 Dec;51(3):526-34.Epub 2007 Sep 24. PMID: 17892475
E.C. number4.2.1.11
Location of functional site(s)Active site:205,339 Binding site:287,164,390,314,155,339 Metal binding site:314,242,287
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionbinds plasminogen and laminin
References for functionAntikainen J, Kuparinen V, L?hteenm?ki K, Korhonen TK. Enolases from Gram-positive bacterial pathogens and commensal lactobacilli share functional similarity in virulence-associated traits. FEMS Immunol Med Microbiol. 2007 Dec;51(3):526-34.Epub 2007 Sep 24. PMID: 17892475
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments