Protein Information

General Information
MoonProt ID303
First appeared in release2.0
Name(s)aldolase, fructose-1,6-bisphosphate aldolase, fructose-bisphosphate aldolase, Gene: LDBPK_361320
UniProt IDE9BTJ1 (E9BTJ1_LEIDB)
GO termsGO:0006096 glycolytic process GO:0003824 catalytic activity GO:0004332 fructose-bisphosphate aldolase activity GO:0016829 lyase activity GO:1903613 regulation of protein tyrosine phosphatase activity
Organisms for which functions have been demonstratedLeishmania donovani
Sequence length371 amino acids
FASTA sequence>tr|E9BTJ1|E9BTJ1_LEIDB Fructose-bisphosphate aldolase OS=Leishmania donovani (strain BPK282A1) GN=LDBPK_361320 PE=3 SV=1 MSRVTIFQSQLPACNRLKTPYESELIATVKKLTTPGKGLLAADESIGSCTKRFEPIGLSNTEEHRRQYRALMLEAEGFEQYISGVILHEETVGQKASNGQTFPEYLTARGVVPGIKTDMGLCPLLEGAEGEQMTEGLDGYVKRASAYYKKGCRFCKWRNVYKIQNGTVSESAVRFNAETLARYAILSQISGLVPIVEPEVMIDGKHDIDTCQRVSEHVWREVVAALQRHGVIWEGCLLKPNMVVPGAESGQTAAPAQVAHYTVMTLARTMPAMLPGVMFLSGGLSEVQASEYLNAINNSPLPRPYFLSFSYARALQSSALKAWGGKDSGVAAGRRAFLHRARMNSMAQLGKYKRADDDASSSSLYVKGNTY
Structure Information
PDB IDNone, but structures available from L. mexicana aldolase
Quaternary structure
Function 1
Function descriptionaldolase, cleavage of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate, in glycolysis
References for functionDowning, Tim, et al. "Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance." Genome research 21.12 (2011): 2143-2156. PMID: 22038251.
E.C. number4.1.2.13
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionActivation of mouse (host) macrophage protein tyrosine phosphatase-1 (SHP-1), causes macrophage disfunction
References for function
E.C. number
Location of functional site(s)
Cellular location of functionsecreted
Comments