Protein Information

General Information
MoonProt ID304
First appeared in release2.0
Name(s)aldolase, fructose-1,6-bisphosphate aldolase, fructose-bisphosphate aldolase, muscle-type aldolase, aldolase 1, Gene: Aldoa
UniProt IDP05064 (ALDOA_MOUSE)
GO termsGO:0006000 fructose metabolic process GO:0006096 glycolytic process GO:0006754 ATP biosynthetic process GO:0006941 striated muscle contraction GO:0008360 regulation of cell shape GO:0030388 fructose 1,6-bisphosphate metabolic process GO:0046716 muscle cell cellular homeostasis GO:0051289 protein homotetramerization GO:0061615 glycolytic process through fructose-6-phosphate GO:0002020 protease binding GO:0003824 catalytic activity GO:0004332 fructose-bisphosphate aldolase activity GO:0008092 cytoskeletal protein binding GO:0016829 lyase activity GO:0044822 poly(A) RNA binding GO:0070061 fructose binding GO:0005515 protein binding
Organisms for which functions have been demonstratedMus musculus (mouse)
Sequence length364 amino acids
FASTA sequence>sp|P05064|ALDOA_MOUSE Fructose-bisphosphate aldolase A OS=Mus musculus GN=Aldoa PE=1 SV=2 MPHPYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHVYLEGTLLKPNMVTPGHACTQKFSNEEIAMATVTALRRTVPPAVTGVTFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYIKRALANSLACQGKYTPSGQSGAAASESLFISNHAY
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionaldolase, in glycolysis and gluconeogenesis, reversible cleavage of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate.
References for functionMestek, A., et al. "Sequence of a mouse brain aldolase A cDNA." Nucleic acids research 15.24 (1987): 10595.
E.C. number
Location of functional site(s)binding site: 56, 147; active site: 188, 230; site: 364
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionbind to and regulate insulin-dependent glucose transporter GLUT4
References for functionKao AW, Noda Y, Johnson JH, Pessin JE, Saltiel AR. Aldolase mediates the association of F-actin with the insulin-responsive glucose transporter GLUT4. J Biol Chem. 1999 Jun 18;274(25):17742-7. PMID: 10364216.
E.C. number
Location of functional site(s)
Cellular location of functioncytoplasm
CommentsGLUT4 is in adipoase tissue, skeletal muscle, cardiac muscle