Protein Information

General Information
MoonProt ID307
First appeared in release2.0
Name(s)aldolase A, ALDOA, Fructose-bisphosphate aldolase A, lung cancer antigen NY-LU-1, Muscle-type aldolase Gene: ALDOA
UniProt IDP04075 (ALDOA_HUMAN)
GO termsGO:0002576 platelet degranulation GO:0006000 fructose metabolic process GO:0006094 gluconeogenesis GO:0006096 glycolytic process GO:0006754 ATP biosynthetic process GO:0006941 striated muscle contraction GO:0007015 actin filament organization GO:0008360 regulation of cell shape GO:0030388 fructose 1,6-bisphosphate metabolic process GO:0046716 muscle cell cellular homeostasis GO:0051289 protein homotetramerization GO:0061621 canonical glycolysis GO:0003779 actin binding GO:0003824 catalytic activity GO:0004332 fructose-bisphosphate aldolase activity GO:0005515 protein binding GO:0008092 cytoskeletal protein binding GO:0015631 tubulin binding GO:0005515 protein binding
Organisms for which functions have been demonstratedHomo sapiens (human)
Sequence length364 amino acids
FASTA sequence>sp|P04075|ALDOA_HUMAN Fructose-bisphosphate aldolase A OS=Homo sapiens GN=ALDOA PE=1 SV=2 MPYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKFSHEEIAMATVTALRRTVPPAVTGITFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPSGQAGAAASESLFVSNHAY
Structure Information
PDB ID4ALD
Quaternary structure
Function 1
Function descriptionaldolase, D-fructose 1,6-bisphosphate-> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate, in glycolysis
References for functionEl-Maghrabi, M. Raafat, et al. "Human fructose-1, 6-bisphosphatase gene (FBP1): exon-intron organization, localization to chromosome bands 9q22. 2-q22. 3, and mutation screening in subjects with fructose-1, 6-bisphosphatase deficiency." Genomics 27.3 (1995): 520-525.
E.C. number
Location of functional site(s)binding site: 56, 147; active site: 188, 230; site: 364
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptioninteractions with zona pellucida proteins of egg
References for functionPetit FM, Serres C, Bourgeon F, Pineau C, Auer J. (2013) Identification of sperm head proteins involved in zona pellucida binding. Hum. Reprod. 28, 852–865. PMID: 23355646.
E.C. number
Location of functional site(s)
Cellular location of functionhead of sperm, sperm membrane
Comments