Protein Information

General Information
MoonProt ID311
First appeared in release2.0
Name(s)beta-arrestin-2, Gene: ARRB2
UniProt IDP32121 (ARRB2_HUMAN)
GO termsGO:0001932 regulation of protein phosphorylation GO:0001934 positive regulation of protein phosphorylation GO:0002031 G-protein coupled receptor internalization GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin GO:0002092 positive regulation of receptor internalization GO:0006366 transcription from RNA polymerase II promoter GO:0006810 transport GO:0006897 endocytosis GO:0007165 signal transduction GO:0007179 transforming growth factor beta receptor signaling pathway GO:0007186 G-protein coupled receptor signaling pathway GO:0007212 dopamine receptor signaling pathway GO:0007420 brain development GO:0007628 adult walking behavior GO:0008277 regulation of G-protein coupled receptor protein signaling pathway GO:0009968 negative regulation of signal transduction GO:0015031 protein transport GO:0006351 transcription, DNA-templated
Organisms for which functions have been demonstratedHomo sapiens
Sequence length409 amino acids
FASTA sequence>sp|P32121|ARRB2_HUMAN Beta-arrestin-2 OS=Homo sapiens GN=ARRB2 PE=1 SV=2 MGEKPGTRVFKKSSPNCKLTVYLGKRDFVDHLDKVDPVDGVVLVDPDYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLFIATYQAFPPVPNPPRPPTRLQDRLLRKLGQHAHPFFFTIPQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSLEEKSHKRNSVRLVIRKVQFAPEKPGPQPSAETTRHFLMSDRSLHLEASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYADICLFSTAQYKCPVAQLEQDDQVSPSSTFCKVYTITPLLSDNREKRGLALDGKLKHEDTNLASSTIVKEGANKEVLGILVSYRVKVKLVVSRGGDVSVELPFVLMHPKPHDHIPLPRPQSAAPETDVPVDTNLIEFDTNYATDDDIVFEDFARLRLKGMKDDDYDDQLC
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionuncouple activated seven-transmembrane receptors from heterotrimeric G proteins, mediate the endocytosis of most G-protein-coupled receptors (GPCRs)
References for functionMcDonald, Patricia H., et al. "Beta-Arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3." Science 290.5496 (2000): 1574-1577.
E.C. number
Location of functional site(s)cytoplasm
Cellular location of function
Comments
Function 2
Function descriptionregulates transcription
References for functionNeuhaus EM, Mashukova A, Barbour J, Wolters D, Hatt H. Novel function of beta-arrestin2 in the nucleus of mature spermatozoa. J Cell Sci. 2006 Aug 1;119(Pt 15):3047-56. PMID: 16820410.
E.C. number
Location of functional site(s)nucleus
Cellular location of function
Comments