Protein Information

General Information
MoonProt ID312
First appeared in release2.0
Name(s)C5a peptidase, Streptococcal C5a peptidase, Gene: ScpB
UniProt IDQ8E4T9 (Q8E4T9_STRA3)
GO termsGO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity GO:0008233 peptidase activity GO:0008236 serine-type peptidase activity GO:0016787 hydrolase activity GO:0005515 protein binding GO:0098631 cell adhesion mediator GO:0005618 cell wall GO:0016020 membrane GO:0016021 integral component of membrane
Organisms for which functions have been demonstratedStreptococcus agalactiae, group B streptococci (GBS)
Sequence length1150 amino acids
FASTA sequence>tr|Q8E4T9|Q8E4T9_STRA3 Streptococcal C5a peptidase OS=Streptococcus agalactiae serotype III (strain NEM316) GN=scpB PE=3 SV=1 MRKKQKLPFDKLAIALMSTSILLNAQSDIKANTVTEDTPATEQTVETPQPTAVSEEAPSSKETKTPQTPSDAGETVADDANDLAPQAPAKTADTPATSKATIRDLNDPSQVKTLQEKAGKGAGTVVAVIDAGFDKNHEAWRLTDKAKARYQSKEDLEKAKKEHGITYGEWVNDKVAYYHDYSKDGKTAVDQEHGTHVSGILSGNAPSETKEPYRLEGAMPEAQLLLMRVEIVNGLADYARNYAQAIRDAINLGAKVINMSFGNAALAYANLPDETKKAFDYAKSKGVSIVTSAGNDSSFGGKTRLPLADHPDYGVVGTPAAADSTLTVASYSPDKQLTETATVKTADQQDKEMPVLSTNRFEPNKAYDYAYANRGTKEDDFKDVKGKIALIERGDIDFKDKIAKAKKAGAVGVLIYDNQDKGFPIELPNVDQMPAAFISRKDGLLLKDNPQKTITFNATPKVLPTASGTKLSRFSSWGLTADGNIKPDIAAPGQDILSSVANNKYAKLSGTSMSAPLVAGIMGLLQKQYETQYPDMTPSERLDLAKKVLMSSATALYDEDEKAYFSPRQQGAGAVDAKKASAATMYVTDKDNTSSKVHLNNVSDKFEVTVTVHNKSDKPQELYYQATVQTDKVDGKHFALAPKALYETSWQKITIPANSS
Structure Information
PDB IDNone, but some structures from very close homologues are available
Quaternary structure
Function 1
Function descriptionprotease, peptidase, endopeptidase, cleaves and inactivates C5a (a component of the human complement system), helps GBS evade phagocytosis
References for functionCleary, P. PATRICK, et al. "Streptococcal C5a peptidase is a highly specific endopeptidase." Infection and immunity 60.12 (1992): 5219-5223.
E.C. number
Location of functional site(s)
Cellular location of functioncell surface
Comments
Function 2
Function descriptionfibronectin binding, adhesin
References for functionBeckmann C, Waggoner JD, Harris TO, Tamura GS, Rubens CE: Identification of novel adhesins from Group B streptococci by use of phage display reveals that C5a peptidase mediates fibronectin binding. Infect Immun 2002, 70(6):2869-2876. PMID: 12010974.
E.C. number
Location of functional site(s)
Cellular location of functioncell surface
Comments