Protein Information

General Information
MoonProt ID313
First appeared in release2.0
Name(s)CALM, Phosphatidylinositol-binding clathrin assembly protein, Gene: PICALM
UniProt IDQ13492 (PICAL_HUMAN)
GO termsGO:0006461 protein complex assembly GO:0006897 endocytosis GO:0006898 receptor-mediated endocytosis GO:0008283 cell proliferation GO:0010629 negative regulation of gene expression GO:0016188 synaptic vesicle maturation GO:0016192 vesicle-mediated transport GO:0016197 endosomal transport GO:0030100 regulation of endocytosis GO:0031623 receptor internalization GO:0032880 regulation of protein localization GO:0035459 cargo loading into vesicle GO:0045893 positive regulation of transcription, DNA-templated GO:0048261 negative regulation of receptor-mediated endocytosis GO:0048268 clathrin coat assembly GO:0055072 iron ion homeostasis GO:0072583 clathrin-mediated endocytosis GO:0097459 iron ion import into cell GO:1901216 positive regulation of neuron death GO:1902004 positive regulation of beta-amyloid formation GO:1902959 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process GO:1902963 negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process GO:0005515 protein binding GO:0005543 phospholipid binding GO:0005545 1-phosphatidylinositol binding GO:0030276 clathrin binding GO:0032050 clathrin heavy chain binding GO:0035615 clathrin adaptor activity GO:0005634 nucleus GO:0005794 Golgi apparatus GO:0005905 coated pit GO:0005905 coated pit GO:0016020 membrane GO:0030136 clathrin-coated vesicle GO:0031410 cytoplasmic vesicle GO:0031982 vesicle GO:0042734 presynaptic membrane GO:0043025 neuronal cell body GO:0045211 postsynaptic membrane GO:0097418 neurofibrillary tangle GO:0030122 AP-2 adaptor complex GO:0030132 clathrin coat of coated pit GO:0048471 perinuclear region of cytoplasm GO:0006351 transcription, DNA-templated
Organisms for which functions have been demonstratedHomo sapiens
Sequence length652 amino acids
FASTA sequence>sp|Q13492|PICAL_HUMAN Phosphatidylinositol-binding clathrin assembly protein OS=Homo sapiens GN=PICALM PE=1 SV=2 MSGQSLTDRITAAQHSVTGSAVSKTVCKATTHEIMGPKKKHLDYLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGDPFSATVDAVDDAIPSLNPFLTKSSGDVHLSISSDVSTFTTRTPTHEMFVGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMAPPVMAYPATTPTGMIGYGIPPQMGSVPVMTQPTLIYSQPVMRPPNPFGPVSGAQIQFM
Structure Information
PDB ID1HF8, 3ZYK, 3ZYM, 3ZYL
Quaternary structure
Function 1
Function descriptionbinds clathrin in endocytosis, assembly protein helps bring clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly
References for functionTebar F., Bohlander S.K., Sorkin A. Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic. Mol. Biol. Cell 10:2687-2702(1999). PMID: 10436022.
E.C. number
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptiontranscription activation
References for functionVecchi M, Polo S, Poupon V, van de Loo JW, Benmerah A, Di Fiore PP. Nucleocytoplasmic shuttling of endocytic proteins. J Cell Biol. 2001 Jun 25;153(7):1511-7. PMID: 11425879.
E.C. number
Location of functional site(s)
Cellular location of functionnucleus
Comments