Protein Information

General Information
MoonProt ID314
First appeared in release2.0
Name(s)Csn7, COP9 signalosome complex subunit 7 Gene: CSN7
UniProt IDQ9V4S8 (CSN7_DROME)
GO termsGO:0000338 protein deneddylation GO:0007095 mitotic G2 DNA damage checkpoint GO:0007275 multicellular organism development GO:0007281 germ cell development GO:0010388 cullin deneddylation GO:0019233 sensory perception of pain GO:0030154 cell differentiation GO:0036099 female germ-line stem cell population maintenance GO:0046331 lateral inhibition GO:0048140 male germ-line cyst encapsulation GO:0048142 germarium-derived cystoblast division GO:0048477 oogenesis GO:0050821 protein stabilization GO:0051726 regulation of cell cycle GO:0005515 protein binding GO:0019781 NEDD8 activating enzyme activity GO:0005634 nucleus GO:0005737 cytoplasm GO:0008180 COP9 signalosome GO:0034399 nuclear periphery GO:0005515 protein binding
Organisms for which functions have been demonstratedDrosophila melanogaster
Sequence length278 amino acids
FASTA sequence>sp|Q9V4S8|CSN7_DROME COP9 signalosome complex subunit 7 OS=Drosophila melanogaster GN=CSN7 PE=1 SV=2 MTQDMLLGNEEPSKSKETFLEKFCVLAKSSTGAALLDVIRQALEAPNVFVFGELLAEPSVLQLKDGPDSKHFETLNLFAYGTYKEYRAQPEKFIELTPAMQKKLQHLTIVSLAIKAKSIPYALLLSELEIDNVRHLEDIIIEAIYADIIHGKLFQNTRILEVDYAQGRDIPPGYTGQIVETLQAWVNSCDSVSNCIEMQIKYANAEKSKRLINKERVEQDLINLKKVLKSQTSDSDESMQIDTHGPGTSGGLGQSELRKKPSKLRNPRSAAVGLKFSK
Structure Information
PDB IDnone, closest homologues has 48% amino acid sequence identity
Quaternary structurepart of a multiprotein complex, the COP9 signalosome
Function 1
Function descriptionpart of COP9 signalosome (CSN), in ubiquitin-mediated protein degradation, CSN removes the ubiquitin-like protein Nedd8 from the cullin subunit of cullin-RING E3 ligase (CRL)
References for functionSinger, R., Atar, S., Atias, et al. (2014) Drosophila COP9 signalosome subunit 7 interacts with multiple genomic loci to regulate development. Nucleic Acids Res. 42, 9761–9770. PMID: 25106867
E.C. number
Location of functional site(s)
Cellular location of functionnucleus
Comments
Function 2
Function descriptionpromote degradation of cyclin E, regulate ubiquitin-proteasome pathway
References for functionDoronkin, Sergey, Inna Djagaeva, and Steven K. Beckendorf. "The COP9 signalosome promotes degradation of Cyclin E during early Drosophila oogenesis." Developmental cell 4.5 (2003): 699-710.
E.C. number
Location of functional site(s)
Cellular location of functionmembrane
Comments