Protein Information

General Information
MoonProt ID316
First appeared in release2.0
Name(s)DPP4, dipeptidyl peptidase 4, Gene: DPP4
UniProt IDP27487 (DPP4_HUMAN)
GO termsGO:0001662 behavioral fear response GO:0001666 response to hypoxia GO:0006508 proteolysis GO:0007155 cell adhesion GO:0008284 positive regulation of cell proliferation GO:0010716 negative regulation of extracellular matrix disassembly GO:0031295 T cell costimulation GO:0033632 regulation of cell-cell adhesion mediated by integrin GO:0035641 locomotory exploration behavior GO:0036343 psychomotor behavior GO:0042110 T cell activation GO:0043542 endothelial cell migration GO:0046718 viral entry into host cell GO:0001618 virus receptor activity GO:0002020 protease binding GO:0004177 aminopeptidase activity GO:0004252 serine-type endopeptidase activity GO:0005102 receptor binding GO:0005515 protein binding GO:0042110 T cell activation
Organisms for which functions have been demonstratedHomo sapiens (human)
Sequence length766 amino acids
FASTA sequence>sp|P27487|DPP4_HUMAN Dipeptidyl peptidase 4 OS=Homo sapiens GN=DPP4 PE=1 SV=2 MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP
Structure Information
PDB ID2QT9, 2BGR, and several others
Quaternary structure
Function 1
Function descriptionserine exopeptidase, dipeptidyl peptidase, regulates several physiological processes by cleaving peptides in the blood, i.e. chemokines, growth factors, neuropeptides, removes N-terminal dipeptides from proteins with unsubstituted N-termini as long as the second residue is proline
References for functionPark J.E., Lenter M.C., Zimmermann R.N., Garin-Chesa P., Old L.J., Rettig W.J. Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts. J. Biol. Chem. 274:36505-36512(1999) PMID: 10593948. Durinx C., Lambeir A.M., Bosmans E., Falmagne J.B., Berghmans R., Haemers A., Scharpe S., De Meester I. Molecular characterization of dipeptidyl peptidase activity in serum: soluble CD26/dipeptidyl peptidase IV is responsible for the release of X-Pro dipeptides.Eur. J. Biochem. 267:5608-5613(2000) PMID: 10951221
E.C. number3.4.14.5
Location of functional site(s)active site: 630, 708, 740
Cellular location of functioncell surface
Comments
Function 2
Function descriptionglycoprotein receptor, involved in T-cell activation, binds ADA, CAV1, IGF2R, and PTPRC
References for function17287217
E.C. number
Location of functional site(s)
Cellular location of functioncell surface
Comments