Protein Information

General Information
MoonProt ID317
First appeared in release2.0
Name(s)DPP10, RE27507p, Gene: CG11319, GenBank NP_609051
UniProt IDQ9VMB4 (Q9VMB4_DROME)
GO termsGO:0008236 serine-type peptidase activity GO:0006508 proteolysis GO:0016020 membrane GO:0016021 Integral component of membrane
Organisms for which functions have been demonstratedDrosophila melanogaster
Sequence length935 amino acids
FASTA sequence>tr|Q9VMB4|Q9VMB4_DROME RE27507p OS=Drosophila melanogaster GN=CG11319 PE=2 SV=3 MPEQDNYDDELVSSNPNQRNWRGILIALLVIIIVLALIVTSVVLLTPPDEGPRVKGQRIKLQDIVDGLFVPQHSNGSWIDGEEFLYQDHLGRICLLNAANRSERVLMSNVTFKTLSPFTFTISADKRYLLLAQNVVKLFRHSYLAQYTLYDIQTSESIKLRHSPHQDEWPYLHYARFTPAGNALVWVQSYDIYYREEVRSASVHRITHDAVPGVVYNGIPDWLYEEEILHANNAIWMSDNGQLMLYATFNDTHVQEQHFAWYGTTGPSAGGAAAAAAVGAGGAGTGSPGAGGSNPHASLYPEIRSLRYPKPGTQNPTVTLRVADLKDPLKVHITDLHPPQIIANEDHYFSSASWVSHSKIAVVWLNRPQNISVVSVCKAPLFQCIETHRVSGDGRGWVDTVAVPLFAANASIYVAISPLRDGLFGYFRHIVHVDIDKNRVLPLTHGPYEVNRLLHWDQLDNWIYFLGTPERLPSQQHLYRVSALPARQGQALRSPDCLTCPAVSQWSEGYDEGHTKSPPKLVTAWDDDWEDSEEAEAQPPQPALPVEQQPPGRGQSAPLPPPPSDCLYHEAKFPISRQAKYVLIDCLGPVVPTSILYGLKSAAADSAKTKRHSTQQEEPPTEGGDEKPGEEPKSQFLELLVIVQNNTRLKEKMAKTAMPQIKTFPVMISGGYHAQVRLYLPPVLREDEITRYPTILHVYSGPGSQLVTDHWHVDWNTYLSGSKDYIVVEIDGRGSAGQGYQLLHEVYKRLGSVEVSDQLEVSEYLRDNLHFIDSRRMGVWGWSYGGYTAALALAGQQSIFQCGISVSPVTNWKLYDSTYAERYLSFPNVTDNYKGYEESDLSKYVDNLRDRQFLLVHGTADDNVHVQQSMVLARSLTSKGVLYKQQIYPDEGHSLSGVKRHLYRSMTAFFEDCFKKLVPPESKAGLGNGGDMQQQ
Structure Information
PDB ID
Quaternary structureauxiliary protein to K+ channel
Function 1
Function descriptionenzyme, dipeptidyl peptidase activity with Gly-Pro-MCA (glycyl-L-proline 4-methylcoumaryl-7-amide) as a substrate
References for functionShiina Y, Muto T, Zhang Z, Baihaqie A, Yoshizawa T, Lee HI, Park E, Tsukiji S, Takimoto K. Fly DPP10 acts as a channel ancillary subunit and possesses peptidase activity. Sci Rep. 2016 May 20;6:26290. doi: 10.1038/srep26290. PMID: 27198182
E.C. number
Location of functional site(s)
Cellular location of function
Commentsmammalian homologue apparently lost enzyme activity during evolution and only has channel regulatory activity
Function 2
Function descriptionancillary subunit of Kv4 channels, bind to pore-forming subunits of voltage-gated K+ channels, causes negative shifts in voltage dependence of channel activation and steady state inactivation
References for functionShiina Y, Muto T, Zhang Z, Baihaqie A, Yoshizawa T, Lee HI, Park E, Tsukiji S, Takimoto K. Fly DPP10 acts as a channel ancillary subunit and possesses peptidase activity. Sci Rep. 2016 May 20;6:26290. doi: 10.1038/srep26290. PMID: 27198182
E.C. number
Location of functional site(s)
Cellular location of function
Comments