Protein Information

General Information
MoonProt ID318
First appeared in release2.0
Name(s)EF-1-alpha, 50 kDa actin-binding protein, ABP-50, Gene: eef1a1
UniProt IDP0CT31 (EF1A1_DICDI)
GO termsGO:0006412 translation GO:0006414 translational elongation GO:0009617 response to bacterium GO:0051017 actin filament bundle assembly GO:0000166 nucleotide binding GO:0003746 translation elongation factor activity GO:0003779 actin binding GO:0003924 GTPase activity GO:0005515 protein binding GO:0005525 GTP binding GO:0051015 actin filament binding GO:0005737 cytoplasm GO:0005938 cell cortex GO:0030027 lamellipodium GO:0030175 filopodium GO:0045335 phagocytic vesicle GO:0005515 protein binding GO:0008076 voltage-gated potassium channel complex
Organisms for which functions have been demonstratedDictyostelium discoideium (slime mold)
Sequence length453 amino acids
FASTA sequence>sp|P0CT31|EF1A1_DICDI Elongation factor 1-alpha OS=Dictyostelium discoideum GN=eef1a1 PE=1 SV=1 MGKEKTHINIVVIGHVDAGKSTTTGHLIYKCGGIDKRVIEKYEKEASEMGKQSFKYAWVMDKLKAERERGITIDIALWKFETSKYYFTIIDAPGHRDFIKNMITGTSQADCAVLVIASPTGEFEAGIAKNGQTREHALLAYTLGVKQMIVAINKMDEKSTNYSQARYDEIVKEVSSFIKKIGYNPEKVAFVPISGWNGDNMLERSDKMEWYKGPTLLEALDAIVEPKRPHDKPLRIPLQDVYKIGGIGTVPVGRVETGIIKPGMVVTFAPAGLSTEVKSVEMHHEQLPEARPGDNVGFNVKNVSVKEIKRGMVAGDSKNDPPQETEKFVAQVIVLNHPGQIHAGYSPVLDCHTAHIACKFTEIVDKVDRRTGAVVAKEGTAAVVLKNGDAAMVELTPSRPMCVESFTEYPPLGRFAVRDMRQTVAVGVIKSTVKKAPGKAGDKKGAAAPSKKK
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionelongation factor
References for functionYang, Fan, et al. "Identification of an actin-binding protein from Dictyostelium as elongation factor 1a." Nature 347.6292 (1990): 494-496.
E.C. number
Location of functional site(s)nucleotide binding: 14-21, 91-95, 153-156
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionregulate cell motility by assembling actin filament
References for functionMurray JW, Edmonds BT, Liu G, Condeelis J. Bundling of actin filaments by elongation factor 1 alpha inhibits polymerization at filament ends .J Cell Biol. 1996 Dec;135(5):1309-21. PMID: 8947553.
E.C. number
Location of functional site(s)
Cellular location of functioncytoplasm
Comments