Protein Information

General Information
MoonProt ID319
First appeared in release2.0
Name(s)EF-1alpha, elongation factor 1alpha,EF-1-alpha-1, Elongation factor Tu, EF-Tu, Eukaryotic elongation factor 1 A-1, eEF1A-1, Leukocyte receptor cluster member 7 Gene: EEF1A1
UniProt IDP68104 (EF1A1_HUMAN)
GO termsGO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006412 translation GO:0006414 translational elongation GO:0071364 cellular response to epidermal growth factor stimulus GO:1904714 regulation of chaperone-mediated autophagy GO:0000049 tRNA binding GO:0000166 nucleotide binding GO:0003746 translation elongation factor activity GO:0003924 GTPase activity GO:0005515 protein binding GO:0005525 GTP binding GO:0019901 protein kinase binding GO:0044822 poly(A) RNA binding GO:0005615 extracellular space GO:0005634 nucleus GO:0005730 nucleolus GO:0005737 cytoplasm GO:0005829 cytosol GO:0005853 eukaryotic translation elongation factor 1 complex GO:0016020 membrane GO:0030864 cortical actin cytoskeleton GO:0032587 ruffle membrane GO:0070062 extracellular exosome GO:0098574 cytoplasmic side of lysosomal membrane GO:0005634 nucleus GO:0008017 microtubule binding
Organisms for which functions have been demonstratedHomo sapiens (human)
Sequence length462 amino acids
FASTA sequence>sp|P68104|EF1A1_HUMAN Elongation factor 1-alpha 1 OS=Homo sapiens GN=EEF1A1 PE=1 SV=1 MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKKIGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGNASGTTLLEALDCILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPPLGRFAVRDMRQTVAVGVIKAVDKKAAGAGKVTKSAQKAQKAK
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptiontranslation elongation factor
References for functionBRANDS, Jolanda HGM, et al. "The primary structure of the alpha subunit of human elongation factor 1." The FEBS Journal 155.1 (1986): 167-171.
E.C. number
Location of functional site(s)nucleotide binding: 14-21, 91-95, 153-156
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionbinds and severs microtubules
References for functionShiina N, Gotoh Y, Kubomura N, Iwamatsu A, Nishida E. Microtubule severing by elongation factor 1 alpha. Science. 1994 266(5183):282-5. PMID: 7939665.
E.C. number
Location of functional site(s)
Cellular location of functioncytoplasm
Comments