Protein Information

General Information
MoonProt ID320
First appeared in release2.0
Name(s)EF-1alpha, elongation factor 1-alpha
UniProt IDQ95VF2 (Q95VF2_LEIDO)
GO termsGO:0006414 translational elongation GO:0000166 nucleotide binding GO:0003746 translation elongation factor activity GO:0003924 GTPase activity GO:0005525 GTP binding GO:0005737 cytoplasm GO:0005515 protein binding
Organisms for which functions have been demonstratedLeishmania donovani
Sequence length449 amino acids
FASTA sequence>tr|Q95VF2|Q95VF2_LEIDO Elongation factor 1-alpha (Fragment) OS=Leishmania donovani PE=2 SV=1 MGKDKVHMNLVVVGHVDAGKSTATGHLIYKCGGIDKRTIEKFEKEAAEIGKASFKYAWVLDKLKAERERGITIDIALWKFESPKSVFTIIDAPGHRDFIKNMITGTSQADAAILMIDSTHGGFEAGISKDGQTREHALLAFTLGVKQMVVCCNKMDDKTVTYAQSRYDEISKEVGAYLKRVGYNPEKVRFIPISGWQGDNMIERSDNMPWYKGPTLLDALDMLEPPVRPVDKPLRLPLQDVYKIGGIGTVPVGRVETGIMKPGDVVTFAPANVTTEVKSIEMHHEQLAEAQPGDNVGFNVKNVSVKDIRRGNVCGNSKNDPPKEAADFTAQVIVLNHPGQISNGYAPVLDCHTSHIACRFAEIESKIDRRSGKELEKNPKAIKSGDAAIVKMVPQKPMCVEVFNDYAPLGRFAVRDMRQTVAVGIIKGVNKKEGSGGKVTKAAAKAAKK
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptiontranslation elongation factor, the rate and fidelity of protein translation
References for functionNandan, Devki, et al. "Molecular cloning, biochemical and structural analysis of elongation factor-1-alpha from Leishmania donovani: comparison with the mammalian homologue." Biochemical and biophysical research communications 302.4 (2003): 646-652.
E.C. number
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionbinds to and activates Src homology 2 domain containing tyrosine phosphatase-1 (SHP-1) in host macrophages, inhibits activity of infected macrophages
References for function12384497
E.C. number
Location of functional site(s)
Cellular location of functionsecreted, acts in host cells
Comments