Protein Information

General Information
MoonProt ID322
First appeared in release2.0
Name(s)EF-1alpha, elongation factor 1 alpha
UniProt IDP17506 (EF1A1_XENLA)
GO termsGO:0006412 translation GO:0006414 translational elongation GO:0000166 nucleotide binding GO:0003746 translation elongation factor activity GO:0003924 GTPase activity GO:0005515 protein binding GO:0005525 GTP binding GO:0005737 cytoplasm GO:0008017 microtubule binding GO:0051013 microtubule servering GO:0005515 protein binding
Organisms for which functions have been demonstratedXenopus laevis (African clawed frog)
Sequence length463 amino acids
FASTA sequence>sp|P17506|EF1A1_XENLA Elongation factor 1-alpha OS=Xenopus laevis PE=1 SV=2 MTDKAPQKTHLNIVIIGHVDSGKSTTTGHLIYKCGGFDPRALEKVEAAAAQLGKSSFKFAWILDKLKAERERGITIDISLWKFQTNRFTITIIDAPGHRDFIKNMITGTSQADVALLVVSAATGEFEAGVSRNGQTREHALLAYTMGVKQLIVCVNKMDLTDPPYSHKRFDEVVRNVMVYLKKIGYNPATIPFVPVSGWTGENISSPSQKMGWFKGWKVKRKDGFTKGQSLLEVLDALVPPVRPANKPLRLPLQDVYKIGGIGTVPVGKIETGILKPGMTISFAPSGFSAEVKSIEMHHEPLQMAFPGFNIGFNVKNIAVKSLKRGNVAGNSKSDPPTEASSFTAQVIILNHPGFIKAGYSPVIDCHTAHITCQFAELQEKIDRRTGKKLEDNPGLLKSGDAAIITLKPIKPFCVERFFDYPPLGRFAARDLKQTVAVGVVKSVEHKAGAAARRQVQKPVLVK
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptiontranslation elongation factor
References for functionKrieg, Paul A., et al. "The mRNA encoding elongation factor 1-alpha (EF-1-alpha) is a major transcript at the midblastula transition in Xenopus." Developmental biology 133.1 (1989): 93-100.
E.C. number
Location of functional site(s)nucleotide binding: 17-24, 94-98, 156-159
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionbinds and severs microtubules
References for functionShiina N, Gotoh Y, Kubomura N, Iwamatsu A, Nishida E. Microtubule severing by elongation factor 1 alpha. Science. 1994 266(5183):282-5. PMID: 7939665.
E.C. number
Location of functional site(s)
Cellular location of functioncytoplasm
Comments