Protein Information

General Information
MoonProt ID328
First appeared in release2.0
Name(s)elongation factor 2, EF2, EF-2, Gene: EEF2
UniProt IDP13639 (EF2_HUMAN)
GO termsGO:0051593 response to folic acid GO:1990416 cellular response to brain-derived neurotrophic factor stimulus GO:2000767 positive regulation of cytoplasmic translation GO:0000166 nucleotide binding GO:0002039 p53 binding GO:0003723 RNA binding GO:0003746 translation elongation factor activity GO:0003924 GTPase activity GO:0005515 protein binding GO:0005525 GTP binding GO:0008097 5S rRNA binding GO:0019901 protein kinase binding GO:0043022 ribosome binding GO:0044822 poly(A) RNA binding GO:0051015 actin filament binding GO:0005634 nucleus GO:0005737 cytoplasm GO:0005829 cytosol GO:0005844 polysome GO:0005886 plasma membrane GO:0016020 membrane GO:0016235 aggresome GO:0030529 intracellular ribonucleoprotein complex GO:0042788 polysomal ribosome GO:0045121 membrane raft GO:0070062 extracellular exosome GO:0005515 protein binding
Organisms for which functions have been demonstratedHomo sapiens (human)
Sequence length858 amino acids
FASTA sequence>sp|P13639|EF2_HUMAN Elongation factor 2 OS=Homo sapiens GN=EEF2 PE=1 SV=4 MVNFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIASARAGETRFTDTRKDEQERCITIKSTAISLFYELSENDLNFIKQSKDGAGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEELYQTFQRIVENVNVIISTYGEGESGPMGNIMIDPVLGTVGFGSGLHGWAFTLKQFAEMYVAKFAAKGEGQLGPAERAKKVEDMMKKLWGDRYFDPANGKFSKSATSPEGKKLPRTFCQLILDPIFKVFDAIMNFKKEETAKLIEKLDIKLDSEDKDKEGKPLLKAVMRRWLPAGDALLQMITIHLPSPVTAQKYRCELLYEGPPDDEAAMGIKSCDPKGPLMMYISKMVPTSDKGRFYAFGRVFSGLVSTGLKVRIMGPNYTPGKKEDLYLKPIQRTILMMGRYVEPIEDVPCGNIVGLVGVDQFLVKTGTITTFEHAHNMRVMKFSVSPVVRVAVEAKNPADLPKLVEGLKRLAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHACIPIKKSDPVVSYRETVSEESNVLCLSKSPNKHNRLYMKARPFPDGLAEDIDKGEVSARQELKQRARYLAEKYEWDVAEARKIWCFGPDGTGPNILTDITKGVQYLNEIKDSVVAGFQWATKEGALCEENMRGVRFDVHDVTLHADAIHRGGGQIIPTARRCLYASVLTAQPRLMEPIYLVEIQCPEQVVGGIYGVLNRKRGHVFEESQVAGTPMFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQILPGDPFDNSSRPSQVVAETRKRKGLKEGIPALDNFLDKL
Structure Information
PDB ID3J3A, 4W22
Quaternary structure
Function 1
Function descriptiontranslation elongation factor
References for functionRAPP, Georg, et al. "Complete sequence of the coding region of human elongation factor 2 (EF-2) by enzymatic amplification of cDNA from human ovarian granulosa cells." Biological Chemistry Hoppe-Seyler 370.2 (1989): 1071-1076.
E.C. number
Location of functional site(s)nucleotide binding: 26-33, 104-108, 158-161
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionbinding partner for Akt2 signalling molecule
References for functionBottermann K, Reinartz M, Barsoum M, Kötter S, Gödecke A. Systematic Analysis Reveals Elongation Factor 2 and Alpha-Enolase as Novel Interaction Partners of AKT2. PLoS One. 2013 Jun 18;8(6):e66045. PMID: 23823123.
E.C. number
Location of functional site(s)
Cellular location of functioncytoplasm
Comments