Protein Information

General Information
MoonProt ID331
First appeared in release2.0
Name(s)enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase, Gene: eno
UniProt IDQ27727 (ENO_PLAFA)
GO termsGO:0006096 glycolytic process GO:0000287 magnesium ion binding GO:0004634 phosphopyruvate hydratase activity GO:0016829 lyase activity GO:0046872 metal ion binding GO:0000015 phosphopyruvate hydratase complex GO:0005737 cytoplasm GO:0005515 protein binding
Organisms for which functions have been demonstratedPlasmodium falciparum
Sequence length446 amino acids
FASTA sequence>sp|Q27727|ENO_PLAFA Enolase OS=Plasmodium falciparum GN=ENO PE=3 SV=1 MAHVITRINAREILDSRGNPTVEVDLETNLGIFRAAVPSGASTGIYEALELRDNDKSRYLGKGVQKAIKNINEIIAPKLIGMNCTEQKKIDNLMVEELDGSKNEWGWSKSKLGANAILAISMAVCRAGAAPNKVSLYKYLAQLAGKKSDQMVLPVPCLNVINGGSHAGNKLSFQEFMIVPVGAPSFKEALRYGAEVYHTLKSEIKKKYGIDATNVGDEGGFAPNILNANEALDLLVTAIKSAGYEGKVKIAMDVAASEFYNSENKTYDLDFKTPNNDKSLVKTGAQLVDLYIDLVKKYPIVSIEDPFDQDDWENYAKLTAAIGKDVQIVGDDLLVTNPTRITKALEKNACNALLLKVNQIGSITEAIEACLLSQKNNWGVMVSHRSGETEDVFIADLVVALRTGQIKTGAPCRSERNAKYNQLLRIEESLGNNAVFAGEKFRLQLN
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionenolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase, 2-phospho-D-glycerate -> phosphoenolpyruvate, in glycolysis
References for functionMolecular characterisation of the enolase gene from the human malaria parasite Plasmodium falciparum. Evidence for ancestry within a photosynthetic lineage. Read M., Hicks K.E., Sims P.F.G., Hyde J.E. Eur. J. Biochem. 220:513-520(1994). PMID: 8125109
E.C. number4.2.1.11
Location of functional site(s)binding site: 166, 175, 304, 331, 407; active site: 218, 356; metal binding: 253, 304, 331
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionplasminogen binding, also maybe EBP binding, also maybe adhesin
References for functionGhosh AK, Coppens I, Gårdsvoll H, Ploug M, Jacobs-Lorena M.Plasmodium ookinetes coopt mammalian plasminogen to invade the mosquito midgut. Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17153-8. doi: 10.1073/pnas.1103657108. PMID: 21949403
E.C. number
Location of functional site(s)
Cellular location of functioncell surface
Comments
Third Function
Function descriptionligand interacting with mosquito midgut epithelium
References for function21949403
E.C. number
Location of functional site(s)
Cellular location of functioncell surface
Comments