Protein Information

General Information
MoonProt ID333
First appeared in release2.0
Name(s)enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase Gene: eno
UniProt IDF5WVK5 (F5WVK5_STRG1)
GO termsGO:0006096 glycolytic process GO:0000287 magnesium ion binding GO:0004634 phosphopyruvate hydratase activity GO:0016829 lyase activity GO:0046872 metal ion binding GO:0000015 phosphopyruvate hydratase complex GO:0005576 extracellular region GO:0005737 cytoplasm GO:0009986 cell surface GO:0005515 protein binding
Organisms for which functions have been demonstratedStreptococcus gallolyticus
Sequence length432 amino acids
FASTA sequence>tr|F5WVK5|F5WVK5_STRG1 Enolase OS=Streptococcus gallolyticus (strain ATCC 43143 / F-1867) GN=eno PE=3 SV=1 MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGEHEAVELRDGDKSRYNGLGTQKAVDNVNNIIAEAIIGFDVRDQQAIDRAMIALDGTPNKGKLGANAILGVSIAVARAAADYLEVPLYSYLGGFNTKVLPTPMMNIINGGSHSDAPIAFQEFMIVPAGAPTFKEALRWGAEIFHTLKKILKERGLETAVGDEGGFAPKFDGTEDAVETIIKAIETAGYKPGEDVFLGFDCASSEFYDNGIYDYTKFEGEGGAKRTASEQIDYIEELVNKYPIITIEDAMDENDWDGWKELTKRLGKRVQLVGDDFFVTNTSYLERGIKEEAANSILIKVNQIGTLTETFEAIEMAKEAGYTAVVSHRSGETEDSTIADIAVATNAGQIKTGSLSRTDRIAKYNQLLRIEDQLGEVAEYRGLKSFYNLKK
Structure Information
PDB IDno, but some from homologues
Quaternary structure
Function 1
Function descriptionenolase, enzyme, in glycolysis, 2-phosphoglycerate => phosphoenolpyruvate
References for functionLin, I-Hsuan, et al. "Sequencing and comparative genome analysis of two pathogenic Streptococcus gallolyticus subspecies: genome plasticity, adaptation and virulence." PLoS One 6.5 (2011): e20519.
E.C. number4.2.1.11
Location of functional site(s)binding site: 155, 164, 289, 316, 341, 392; active site: 205, 341; metal binding: 242, 289, 316
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionbinds Cytokeratin 8 (CK8) of host cells
References for functionBoleij, A., Laarakkers, C.M., Gloerich, J., Swinkels, D.W. and Tjalsma, H. (2011) Surface-affinity profiling to identify host-pathogen interactions. Infect. Immun. 79, 4777–4783. PMID: 21947776
E.C. number
Location of functional site(s)
Cellular location of functioncell surface
Comments