Protein Information

General Information
MoonProt ID336
First appeared in release2.0
Name(s)eps15, Epidermal growth factor receptor substrate 15, Gene: EPS15
UniProt IDP42566 (EPS15_HUMAN)
GO termsGO:0006810 transport GO:0006895 Golgi to endosome transport GO:0006897 endocytosis GO:0007173 epidermal growth factor receptor signaling pathway GO:0008283 cell proliferation GO:0015031 protein transport GO:0016050 vesicle organization GO:0019065 receptor-mediated endocytosis of virus by host cell GO:0032456 endocytic recycling GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway GO:0046718 viral entry into host cell GO:0048268 clathrin coat assembly GO:0005509 calcium ion binding GO:0005515 protein binding GO:transcription, DNA-templated
Organisms for which functions have been demonstratedHomo sapiens
Sequence length896 amino acids
FASTA sequence>sp|P42566|EPS15_HUMAN Epidermal growth factor receptor substrate 15 OS=Homo sapiens GN=EPS15 PE=1 SV=2 MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFRQSTDPFATSSTDPFSAANNSSITSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESFGGGFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPALPPKIGTPTRPCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNKEADPSNFANFSAYPSEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAIALSKSEISEA
Structure Information
PDB ID1EH2, 1C07, 1F8H, 2JXC, 1FF1
Quaternary structure
Function 1
Function descriptionbinds clathrin, clathrin adapter in post-Golgi trafficking, also role in assembly of clathrin-coated pits
References for functionMettlen M., Stoeber M., Loerke D., Antonescu C.N., Danuser G., Schmid S.L. Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits. Mol. Biol. Cell 20:3251-3260(2009). PMID: 19458185.
E.C. number
Location of functional site(s)calcium binding: 173-184; 236-247
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptiontranscription activation
References for functionVecchi M, Polo S, Poupon V, van de Loo JW, Benmerah A, Di Fiore PP. Nucleocytoplasmic shuttling of endocytic proteins. J Cell Biol. 2001 Jun 25;153(7):1511-7. PMID: 11425879.
E.C. number
Location of functional site(s)
Cellular location of functionnucleus
Comments