Protein Information

General Information
MoonProt ID337
First appeared in release2.0
Name(s)Fructose-1,6-bisphosphatase, FBP1, FBPase 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase 1, Liver FBPase, Gene: FBP1
UniProt IDP09467 (F16P1_HUMAN)
GO termsGO:0005975 carbohydrate metabolic process GO:0006001 fructose catabolic process GO:0006002 fructose 6-phosphate metabolic process GO:0006094 gluconeogenesis GO:0006111 regulation of gluconeogenesis GO:0008152 metabolic process GO:0016311 dephosphorylation GO:0030308 negative regulation of cell growth GO:0035690 cellular response to drug GO:0045820 negative regulation of glycolytic process GO:0046580 negative regulation of Ras protein signal transduction GO:0051289 protein homotetramerization GO:0071286 cellular response to magnesium ion GO:0003824 catalytic activity GO:0005515 protein binding GO:0016208 AMP binding GO:0016787 hydrolase activity GO:0016791 phosphatase activity GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity GO:0042578 phosphoric ester hydrolase activity GO:0042802 identical protein binding GO:0005515 protein binding
Organisms for which functions have been demonstratedHomo sapiens (human)
Sequence length338 amino acids
FASTA sequence>sp|P09467|F16P1_HUMAN Fructose-1,6-bisphosphatase 1 OS=Homo sapiens GN=FBP1 PE=1 SV=5 MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
Structure Information
PDB ID4MJO, 2FIE, 2FHY, 3A29, 1FTA
Quaternary structure
Function 1
Function descriptionfructose-1,6-bisphosphatase 1, enzyme in gluconeogenesis, D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + phosphate
References for functionEl-Maghrabi, M. Raafat, et al. "Human fructose-1, 6-bisphosphatase gene (FBP1): exon-intron organization, localization to chromosome bands 9q22. 2-q22. 3, and mutation screening in subjects with fructose-1, 6-bisphosphatase deficiency." Genomics 27.3 (1995): 520-525.
E.C. number3.1.3.11
Location of functional site(s)metal binding: 69, 98, 119, 121, 122, 281; binding: 141, 265; nucleotide binding: 18-22, 28-32, 113-114
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionbinds to HIF (hypoxia inducible factor) protein and inhibits nuclear HIF action
References for function25043030
E.C. number
Location of functional site(s)
Cellular location of functionnucleus
Commentscatalytic function not needed for this function