Protein Information

General Information
MoonProt ID338
First appeared in release2.0
Name(s)Glyceraldehyde-3-phosphate dehydrogenase, Gene Name: GAPDH
UniProt IDP10096 (G3P_BOVIN)
GO termsGO:0000226 microtubule cytoskeleton organization GO:0006006 glucose metabolic process GO:0006096 glycolytic process GO:0006417 regulation of translation GO:0006915 apoptotic process GO:0035606 peptidyl-cysteine S-trans-nitrosylation GO:0050821 protein stabilization GO:0051402 neuron apoptotic process GO:0055114 oxidation-reduction process GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity GO:0005515 protein binding GO:0008017 microtubule binding GO:0016491 oxidoreductase activity GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016740 transferase activity GO:0035605 peptidyl-cysteine S-nitrosylase activity GO:0050661 NADP binding GO:0051287 NAD binding GO:0005634 nucleus GO:0003697 single-stranded DNA binding
Organisms for which functions have been demonstratedBos taurus
Sequence length333 amino acids
FASTA sequence>sp|P10096|G3P_BOVIN Glyceraldehyde-3-phosphate dehydrogenase OS=Bos taurus GN=GAPDH PE=1 SV=4 MVKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLHYMVYMFQYDSTHGKFNGTVKAENGKLVINGKAITIFQERDPANIKWGDAGAEYVVESTGVFTTMEKAGAHLKGGAKRVIISAPSADAPMFVMGVNHEKYNNTLKIVSNASCTTNCLAPLAKVIHDHFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGAAQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTPNVSVVDLTCRLEKPAKYDEIKKVVKQASEGPLKGILGYTEDQVVSCDFNSDTHSSTFDAGAGIALNDHFVKLISWYDNEFGYSNRVVDLMVHMASKE
Structure Information
PDB ID4O59
Quaternary structure
Function 1
Function descriptionglyceraldehyde 3-phosphate dehydrogenase, enzyme, D-glyceraldehyde 3-phosphate + phosphate + NAD+ => 3-phospho-D-glyceroyl phosphate + NADH
References for functionGrosse F, Nasheuer HP, Scholtissek S, Schomburg U. Lactate dehydrogenase and glyceraldehyde-phosphate dehydrogenase are single-stranded DNA-binding proteins that affect the DNA-polymerase-alpha-primase complex. Eur J Biochem. 1986 Nov 3;160(3):459-67. PMID: 3536507
E.C. number1.2.1.12
Location of functional site(s)binding site: 33, 78, 120, 180, 232, 314; active site: 150; site: 177; nucleotide binding: 11-12
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionsingle stranded DNA binding (SSB), effects on the DNA-polymerase-alpha- primase complex
References for function3536507
E.C. number
Location of functional site(s)
Cellular location of functionnucleus
Comments