Protein Information

General Information
MoonProt ID339
First appeared in release2.0
Name(s)GAPDH, glyceraldehyde-3-phosphate dehydrogenase
UniProt IDP17244 (G3P_CRIGR)
GO termsGO:0000226 microtubule cytoskeleton organization GO:0006006 glucose metabolic process GO:0006096 glycolytic process GO:0006417 regulation of translation GO:0006915 apoptotic process GO:0035606 peptidyl-cysteine S-trans-nitrosylation GO:0050821 protein stabilization GO:0051402 neuron apoptotic process GO:0055114 oxidation-reduction process GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity GO:0008017 microtubule binding GO:0016491 oxidoreductase activity GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016740 transferase activity GO:0035605 peptidyl-cysteine S-nitrosylase activity GO:0050661 NADP binding GO:0051287 NAD binding GO:0005634 nucleus GO:0005737 cytoplasm GO:0005829 cytosol GO:0005856 cytoskeleton GO:0015630 microtubule cytoskeleton GO:0097452 GAIT complex GO:0005515 protein binding
Organisms for which functions have been demonstratedCricetulus griseus, hamster (Chinese hamster, CHO cells)
Sequence length333 amino acids
FASTA sequence>sp|P17244|G3P_CRIGR Glyceraldehyde-3-phosphate dehydrogenase OS=Cricetulus griseus GN=GAPDH PE=2 SV=2 MVKVGVNGFGRIGRLVTRAAFTSGKVEVVAINDPFIDLNYMVYMFQYDSTHGKFKGTVKAENGKLVINGKAITIFQERDPANIKWGDAGAEYVVESTGVFTTMEKAGAHLKGGAKRVIISAPSADAPMFVMGVNQDKYDNSLKIVSNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGAAQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTPNVSVVDLTCRLEKPAKYEDIKKVVKQASEGPLKGILGYTEDQVVSCDFNSDSHSSTFDAGAGIALNDNFVKLISWYDNEFGYSNRVVDLMAYMASKE
Structure Information
PDB IDnone, but several close homologues with >90% amino acid sequence identity
Quaternary structure
Function 1
Function descriptionenzyme, glyceraldehyde 3-phosphate dehydrogenase, D-glyceraldehyde 3-phosphate (G3P) -> 3-phospho-D-glyceroyl phosphate, in glycolysis
References for functionVincent S., Fort P. Nucleotide sequence of hamster glyceraldehyde-3-phosphate dehydrogenase mRNA. Nucleic Acids Res. 18:3054-3054(1990) PMID: 2349105.
E.C. number1.2.1.12
Location of functional site(s)binding site: 33, 78, 120, 180, 232, 314; active site: 150; site: 177; nucleotide binding: 11-12
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptiontransferrin receptor, iron uptake
References for function22062951
E.C. number
Location of functional site(s)
Cellular location of functioncell surface
Comments