Protein Information

General Information
MoonProt ID340
First appeared in release2.0
Name(s)GAPDH, glyceraldehyde-3-phosphate dehydrogenase, Gene: GAPDH
UniProt IDD9IL10 (D9IL10_HAECO)
GO termsGO:0006006 glucose metabolic process GO:0006096 glycolytic process GO:0055114 oxidation-reduction process GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity GO:0016491 oxidoreductase activity GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0050661 NADP binding GO:0051287 NAD binding GO:0005515 protein binding
Organisms for which functions have been demonstratedHaemonchus contortus (Barber pole worm)
Sequence length341 amino acids
FASTA sequence>tr|D9IL10|D9IL10_HAECO Glyceraldehyde-3-phosphate dehydrogenase OS=Haemonchus contortus GN=GAPDH PE=2 SV=1 MVKPKVGINGCGRIGRLVLRAAVEKEPAEVVAVNDPFINIDYMVYLFKYDSTHGRFKGTVAHEGEHLVVSKEGKSTHRIKVHNSKDPAEIKWGADGAEYIVESTGVFTTVEKASAHLKGGAKKVVISAPSADAPMFVMGVNHETYNAANNHIISNASCTTNCLAPLAKVINDNFGIIEGLMTTVHATTATQKTVDGPSGKLWRDGRGAAQNIIPASTGAAKAVGKVIPTLNGKLTGMAFRVPTPDVSVVDLTCRLEKPASMDDIKKVIKSAADGPMKGILGYTEDQVVSTDFVSDTHSSIFDAGACISLNPNFVKLISWYDNEYGYSHRVVDLLAYIASKA
Structure Information
PDB IDNone, but some are available from homologues
Quaternary structure
Function 1
Function descriptionGAPDH, glyceraldehyde-3-phosphate dehydrogenase, in glycolysis, D-glyceraldehyde 3-phosphate + phosphate + NAD+ -> 3-phospho-D-glyceroyl phosphate + NADH
References for functionSahoo S, Murugavel S, Devi IK, Vedamurthy GV, Gupta SC, Singh BP, Joshi P. (2013) Glyceraldehyde-3-phosphate dehydrogenase of the parasitic nematode Haemonchus contortus binds to complement C3 and inhibits its activity. Parasite Immunol. 35, 457–467. PMID: 23927077.
E.C. number1.2.1.12
Location of functional site(s)active site: 158; site: 185; binding site: 188, 240
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionbinding alternative complement pathway protein C3, inhibit complement cascade, evade host immunity
References for function23927077
E.C. number
Location of functional site(s)
Cellular location of functioncell surface
Commentsnematode species infects sheep and goats gastrointestinal tract