Protein Information

General Information
MoonProt ID344
First appeared in release2.0
Name(s)GAPDH, glyceraldehyde-3-phosphate dehydrogenase, Gene: Gapdh
UniProt IDP16858 (G3P_MOUSE)
GO termsGO:0000226 microtubule cytoskeleton organization GO:0006006 glucose metabolic process GO:0006096 glycolytic process GO:0006417 regulation of translation GO:0006915 apoptotic process GO:0007275 multicellular organism development GO:0017148 negative regulation of translation GO:0035606 peptidyl-cysteine S-trans-nitrosylation GO:0050821 protein stabilization GO:0051402 neuron apoptotic process GO:0055114 oxidation-reduction process GO:0071346 cellular response to interferon-gamma GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity GO:0005515 protein binding GO:0008017 microtubule binding GO:0016491 oxidoreductase activity GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016740 transferase activity GO:0019899 enzyme binding GO:0035605 peptidyl-cysteine S-nitrosylase activity GO:0042802 identical protein binding GO:0050661 NADP binding GO:0051287 NAD binding GO:0005634 nucleus GO:0005737 cytoplasm GO:0005739 mitochondrion GO:0005811 lipid particle GO:0005829 cytosol GO:0005856 cytoskeleton GO:0005886 plasma membrane GO:0015630 microtubule cytoskeleton GO:0016020 membrane GO:0030529 intracellular ribonucleoprotein complex GO:0031965 nuclear membrane GO:0031982 vesicle GO:0043209 myelin sheath GO:0043231 intracellular membrane-bounded organelle GO:0070062 extracellular exosome GO:0097452 GAIT complex GO:0003729 mRNA binding GO:0017091 AU-rich element binding
Organisms for which functions have been demonstratedMus musculus (mouse)
Sequence length333 amino acids
FASTA sequence>sp|P16858|G3P_MOUSE Glyceraldehyde-3-phosphate dehydrogenase OS=Mus musculus GN=Gapdh PE=1 SV=2 MVKVGVNGFGRIGRLVTRAAICSGKVEIVAINDPFIDLNYMVYMFQYDSTHGKFNGTVKAENGKLVINGKPITIFQERDPTNIKWGEAGAEYVVESTGVFTTMEKAGAHLKGGAKRVIISAPSADAPMFVMGVNHEKYDNSLKIVSNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGAAQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTPNVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEDQVVSCDFNSNSHSSTFDAGAGIALNDNFVKLISWYDNEYGYSNRVVDLMAYMASKE
Structure Information
PDB IDnone for mouse, but homologues for other species available
Quaternary structuretetramer in glycolysis
Function 1
Function descriptionglyceraldehyde 3-phosphate dehydrogenase, in glycolysis, D-glyceraldehyde 3-phosphate (G3P) <-> 3-phospho-D-glyceroyl phosphate
References for functionSabath, Daniel E., H. Elizabeth Broome, and Michael B. Prystowsky. "Glyceraldehyde-3-phosphate dehydrogenase mRNA is a major interleukin 2-induced transcript in a cloned T-helper lymphocyte." Gene 91.2 (1990): 185-191.
E.C. number1.2.1.12
Location of functional site(s)binding site: 33, 78, 120, 180, 232, 314; active site: 150; site: 177; nucleotide binding: 11-12
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionbind mRNA AU-rich element (ARE), regulation of cyclo-oxygenase-2 (COX-2) expressio, binding to COX-2 mRNA
References for function23000033
E.C. number
Location of functional site(s)
Cellular location of function
Comments