Protein Information

General Information
MoonProt ID345
First appeared in release2.0
Name(s)Glyceraldehyde-3-phosphate dehydrogenase, GAPDH Gene: GAPDH
UniProt IDP46406 (G3P_RABIT)
GO termsGO:0000226 microtubule cytoskeleton organization GO:0006006 glucose metabolic process GO:0006096 glycolytic process GO:0006417 regulation of translation GO:0006915 apoptotic process GO:0035606 peptidyl-cysteine S-trans-nitrosylation GO:0050821 protein stabilization GO:0051402 neuron apoptotic process GO:0055114 oxidation-reduction process GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity GO:0005515 protein binding GO:0008017 microtubule binding GO:0016491 oxidoreductase activity GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016740 transferase activity GO:0035605 peptidyl-cysteine S-nitrosylase activity GO:0050661 NADP binding GO:0051287 NAD binding GO:0005634 nucleus GO:0005737 cytoplasm GO:0005829 cytosol GO:0005856 cytoskeleton GO:0015630 microtubule cytoskeleton GO:0097452 GAIT complex GO:0020037 heme binding
Organisms for which functions have been demonstratedOryctolagus cuniculus, rabbit
Sequence length333 amino acids
FASTA sequence>sp|P46406|G3P_RABIT Glyceraldehyde-3-phosphate dehydrogenase OS=Oryctolagus cuniculus GN=GAPDH PE=1 SV=3 MVKVGVNGFGRIGRLVTRAAFNSGKVDVVAINDPFIDLHYMVYMFQYDSTHGKFHGTVKAENGKLVINGKAITIFQERDPANIKWGDAGAEYVVESTGVFTTMEKAGAHLKGGAKRVIISAPSADAPMFVMGVNHEKYDNSLKIVSNASCTTNCLAPLAKVIHDHFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGAAQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTPNVSVVDLTCRLEKAAKYDDIKKVVKQASEGPLKGILGYTEDQVVSCDFNSATHSSTFDAGAGIALNDHFVKLISWYDNEFGYSNRVVDLMVHMASKE
Structure Information
PDB ID1J0X
Quaternary structuretetramer
Function 1
Function descriptionGlyceraldehyde-3-phosphate dehydrogenase, GAPDH, in glycolysis, conversion of glyceraldehyde 3-phosphate into glycerate 1,3-bisphosphate
References for functionBallas, Samir K. "Comparative distribution of glyceraldehyde 3-phosphate dehydrogenase activity in human, guinea-pig, rabbit and mouse erythrocytes." Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 87.4 (1987): 837-842.
E.C. number1.2.1.12
Location of functional site(s)binding site: 33, 78, 120, 180, 232, 314; active site: 150; site: 177; nucleotide binding: 11-12
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionheme binding protein, required for the insertion of cellular heme into inducible nitric oxide synthase
References for function20921417, 22957700
E.C. number
Location of functional site(s)
Cellular location of functioncytoplasm
Comments