Protein Information

General Information
MoonProt ID346
First appeared in release2.0
Name(s)GAPDH, glyceraldehyde 3-phosphage dehydrogenase, glyceraldehyde-3-phosphgae dehydrogenase, Gene: gapdh
UniProt IDA8C5S7 (A8C5S7_TALMA)
GO termsGO:0006006 glucose metabolic process GO:0006096 glycolytic process GO:0055114 oxidation-reduction process GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity GO:0016491 oxidoreductase activity GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0050661 NADP binding GO:0051287 NAD binding GO:0098631 cell adhesion mediator
Organisms for which functions have been demonstratedTalaromyces marneffei (Penicillium marneffei)
Sequence length337 amino acids
FASTA sequence>tr|A8C5S7|A8C5S7_TALMA Glyceraldehyde-3-phosphate dehydrogenase OS=Talaromyces marneffei GN=gapdh PE=2 SV=1 MVTKVGINGFGRIGRIVFRNVIEHDDAEVVAVNDPFIETHYAAYMLKYDTQHGQFKGTIEVEGSDLIVNGKRVKFYQERDPANIKWSETGAAYIVESTGVFTTTEKASAHLKGGAKKVVISAPSADAPMFVMGVNHTTYKSSDTIISNASCTTNCLAPLAKIVNDNWGLVEGLMTTIHSYTATQKTVDGPSAKDWRGGRTAAQNIIPSSTGAAKAVGKVIPALNGKLTGMSMRVPTSNVSVVDLTCRTEKPVSYDEIKATVKKYAEGELKGIMGYTEDDVVSTDMNGNSNSSVFDAKAGIALNSNFIKLVSWYDNEWGYSRRVVDLIVYISKVDGNA
Structure Information
PDB IDnone, but structures of some homologues available
Quaternary structure
Function 1
Function descriptionGAPDH, in glycolysis, catalyzing the phosphorylation of glyceraldehyde-3-phosphate to D-glycerate 1,3-bisphosphate
References for functionThirach S., Cooper C.R.Jr., Vanittanakom N. Molecular analysis of the Penicillium marneffei glyceraldehyde-3-phosphate dehydrogenase-encoding gene (gpdA) and differential expression of gpdA and the isocitrate lyase-encoding gene (acuD) upon internalization by murine macrophages. J. Med. Microbiol. 57:1322-1328(2008). PMID: 18927407.
E.C. number
Location of functional site(s)active site: 151; site: 178; binding site: 1861, 233
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionadhesin
References for function24128375
E.C. number
Location of functional site(s)
Cellular location of functionsurface
Comments