Protein Information

General Information
MoonProt ID355
First appeared in release2.0
Name(s)HADHB, (hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein) beta -subunit, Trifunctional enzyme subunit beta, mitochondrial, Acetyl-CoA acyltransferase, TP-beta, Beta-ketothiolase, Gene: HADHB
UniProt IDP55084 (ECHB_HUMAN)
GO termsGO:0006629 lipid metabolic process GO:0006631 fatty acid metabolic process GO:0006635 fatty acid beta-oxidation GO:0008152 metabolic process GO:0035965 cardiolipin acyl-chain remodeling GO:0003824 catalytic activity GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity GO:0003988 acetyl-CoA C-acyltransferase activity GO:0004300 enoyl-CoA hydratase activity GO:0005515 protein binding GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity GO:0016740 transferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0044822 poly(A) RNA binding GO:0005739 mitochondrion GO:0005740 mitochondrial envelope GO:0005741 mitochondrial outer membrane GO:0005783 endoplasmic reticulum GO:0016020 membrane GO:0042645 mitochondrial nucleoid GO:0070062 extracellular exosome GO:0003723 RNA binding GO:0003730 mRNA 3-UTR binding
Organisms for which functions have been demonstratedHomo sapiens (human)
Sequence length474 amino acids
FASTA sequence>sp|P55084|ECHB_HUMAN Trifunctional enzyme subunit beta, mitochondrial OS=Homo sapiens GN=HADHB PE=1 SV=3 MTILTYPFKNLPTASKWALRFSIRPLSCSSQLRAAPAVQTKTKKTLAKPNIRNVVVVDGVRTPFLLSGTSYKDLMPHDLARAALTGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRKLMLDLNKAKSMGQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSDVVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKPYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNNWGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK
Structure Information
PDB ID
Quaternary structurepart of multienzyme complex composed of four alpha-subunits (HADHA) with enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase activities and four beta-subunits (HADHB) with 3-ketoacyl-CoA thiolase activity
Function 1
Function descriptionenzyme, 3-ketoacyl-CoA thiolase activity
References for functionHe, Xue-Ying, Horst Schulz, and Song-Yu Yang. "A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in Alzheimer’s disease." Journal of Biological Chemistry 273.17 (1998): 10741-10746.
E.C. number2.3.1.16
Location of functional site(s)active site: 138, 428, 458
Cellular location of function
Comments
Function 2
Function descriptionRNA binding, binds 3'UTR of REN mRNA which results in regulation of renin expression, destabilizes REN mRNA
References for functionAdams DJ, Beveridge DJ, van der Weyden L, Mangs H, Leedman PJ, Morris BJ.HADHB, HuR, and CP1 bind to the distal 3'-untranslated region of human renin mRNA and differentially modulate renin expression. J Biol Chem. 2003 Nov 7;278(45):44894-903. PMID: 12933794
E.C. number
Location of functional site(s)
Cellular location of function
Comments