Protein Information

General Information
MoonProt ID356
First appeared in release2.0
Name(s)Hal3, thymidylate synthase, phosphopantothenoylcysteine decarboxylase, PPCDC, Gene: SPAC15E1.04
UniProt IDQ9UTI7 (TYSY_SCHPO)
GO termsGO:0006231 dTMP biosynthetic process GO:0006235 dTTP biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0032259 methylation GO:0003824 catalytic activity GO:0004799 thymidylate synthase activity GO:0008168 methyltransferase activity GO:0016740 transferase activity GO:0050660 flavin adenine dinucleotide binding GO:0005737 cytoplasm GO:0005515 protein binding GO:0005829 cytosol
Organisms for which functions have been demonstratedSchizosaccharomyces pombe
Sequence length625 amino acids
FASTA sequence>sp|Q9UTI7|TYSY_SCHPO Probable thymidylate synthase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC15E1.04 PE=3 SV=1 MSQPLHARFATRAVKNPMILEKERQLTDSKYHILVAATGSVAAIKLTLIVKSLLTYKGVDVQVVLTDPARNFVEKEDLTALGVNVYNNADDWKNWDGLECPITHIELRRWAHLLLIAPLSANTMAKMANGLCDNLLTSLIRAWAPLKPILLAPAMNTLMWTNPITQEHLSAISRIYKNSEFIMPIEKVLACGDIGMGGMAEWRNIVGRVADKLQLEQKSVLPNAVKNIDGQDDDSSEQTAAFEEYDDDDDDDVDDNEQSNSMIETSANADITPKASLLPSTTESSISKDHETSQAPLGSESVDTQASENVTTKPEPPVPFTSSEYRNTEEEQYLNLIRYILENGQSRPDRTGTGTRSVFAPPQLRFSLRNNTLPLLTTKRVFLRGVLEELLWFIHGDTNANHLSEKGIHIWDGNGSREFLDSRGLTDRKVGDLGPIYGFQWRHFGAQYVDCDTDYTNKGVDQLAQVISTLKLNPYDRRIILSAWNPLAIPEMALPPCHIFCQFYVSEPCKPGGKPQLSSMMYQRSADMGLGVPFNIASYSLLTHMIAHMCGYEAAEFVHVMGDCHIYNDHLEALQTQLERVPKAFPKLFFKRDAKDIGSIDSFSVDDFAVEGYNPYGPIKMKMSV
Structure Information
PDB IDNone, some structures of homologues of TS domain available
Quaternary structurehetero and homo trimers
Function 1
Function descriptionphosphopantothenoylcysteine decarboxylase, decarboxylation of phosphopahtothenoyl-L-cysteine, in CoA biosynthesis, PPCDC
References for functionMolero C, Petrenyi K, Gonzalez A, Carmona M, Gelis S, Abrie JA, Strauss E, Ramos J, Dombradi V, Hidalgo E, Arino J. 2013. The Schizosaccharomyces pombe fusion gene hal3 encodes three distinct activities. Mol Microbiol 90:367-382. PMID: 23962284.
E.C. number4.1.1.36
Location of functional site(s)binding site: 350, 527, 535; active site: 497; nucleotide binding: 477-478; 524-527; 565-567
Cellular location of function
Comments
Function 2
Function descriptioninhibitor of serine/threoinine phosphatase Pzh1
References for function23962284
E.C. number
Location of functional site(s)
Cellular location of function
Comments
Third Function
Function descriptionthymidylate synthase (apparently due to fusion event)
References for function23962284
E.C. number2.1.1.45
Location of functional site(s)
Cellular location of function
Comments