Protein Information

General Information
MoonProt ID358
First appeared in release2.0
Name(s)hexokinase, hexokinase-1, Gene: HK1
UniProt IDP17710 (HXK1_MOUSE)
GO termsGO:0001678 cellular glucose homeostasis GO:0005975 carbohydrate metabolic process GO:0006096 glycolytic process GO:0008152 metabolic process GO:0016310 phosphorylation GO:0019318 hexose metabolic process GO:0046835 carbohydrate phosphorylation GO:0051156 glucose 6-phosphate metabolic process GO:0061621 canonical glycolysis GO:0072655 establishment of protein localization to mitochondrion GO:0072656 maintenance of protein location in mitochondrion GO:0000166 nucleotide binding GO:0003824 catalytic activity GO:0004340 glucokinase activity GO:0004396 hexokinase activity GO:0005515 protein binding GO:0005524 ATP binding GO:0005536 glucose binding GO:0008865 fructokinase activity GO:0016301 kinase activity GO:0016740 transferase activity GO:0016773 phosphotransferase activity, alcohol group as acceptor GO:0019158 mannokinase activity GO:0005739 mitochondrion GO:0005741 mitochondrial outer membrane GO:0005829 cytosol GO:0005929 cilium GO:0016020 membrane GO:0045121 membrane raft GO:0097228 sperm principal piece GO:0030246 carbohydrate binding
Organisms for which functions have been demonstratedMus musculus
Sequence length974 amino acids
FASTA sequence>sp|P17710|HXK1_MOUSE Hexokinase-1 OS=Mus musculus GN=Hk1 PE=1 SV=3 MGWGAPLLSRMLHGPGQAGETSPVPERQSGSENPASEDRRPLEKQCSHHLYTMGQNCQRGQAVDVEPKIRPPLTEEKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKSQNVSMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKESLLFEGRITPELLTRGKFTTSDVAAIETDKEGVQNAKEILTRLGVEPSHDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLSHFRLSKQALMEVKKKLRSEMEMGLRKETNSRATVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCKQTSLDCGILITWTKGFKATDCVGHDVATLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEPSCEIGLIVGTGSNACYMEEMKNVEMVEGNQGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFLLSEDGSGKGAALITAVGVRLRGDPTNA
Structure Information
PDB IDNone, but structures of human and rat homologues
Quaternary structure
Function 1
Function descriptionhexokinase, enzyme, in glycolysis, ATP + D-hexose => D-hexose 6-phosphate + ADP
References for functionArora, Krishan K., Maurizio Fanciulli, and Peter L. Pedersen. "Glucose phosphorylation in tumor cells. Cloning, sequencing, and overexpression in active form of a full-length cDNA encoding a mitochondrial bindable form of hexokinase." Journal of Biological Chemistry 265.11 (1990): 6481-6488.
E.C. number2.7.1.1
Location of functional site(s)binding site: 86, 211, 265, 288, 291, 316, 505, 659, 713, 736, 739, 764, 798, 953; nucleotide binding: 140-145, 481-482, 588-593, 803-804, 840-844, 919-923
Cellular location of functionsurface of mitochondria, cytoplasm
Comments
Function 2
Function descriptionreceptor for bacterial NAG (N-acetylglucosamine), activates inflammasome response
References for function27374331
E.C. number
Location of functional site(s)
Cellular location of functionmoves from outer membrane of mitochondria to cytoplasm
Commentsbinding of NAG results in release of hexokinase from outer membrane of mitochondria