Protein Information

General Information
MoonProt ID359
First appeared in release2.0
Name(s)hexokinase 1, Gene: HXK1
UniProt IDQ42525 (HXK1_ARATH)
GO termsGO:0001678 cellular glucose homeostasis GO:0005975 carbohydrate metabolic process GO:0006096 glycolytic process GO:0010148 transpiration GO:0010182 sugar mediated signaling pathway GO:0010255 glucose mediated signaling pathway GO:0012501 programmed cell death GO:0016310 phosphorylation GO:0019320 hexose catabolic process GO:0046835 carbohydrate phosphorylation GO:0051156 glucose 6-phosphate metabolic process GO:0090332 stomatal closure GO:0009750 response to fructose GO:0000166 nucleotide binding GO:0004340 glucokinase activity GO:0004396 hexokinase activity GO:0005515 protein binding GO:0005524 ATP binding GO:0005536 glucose binding GO:0008270 zinc ion binding GO:0008865 fructokinase activity GO:0016301 kinase activity GO:0016740 transferase activity GO:0016773 phosphotransferase activity, alcohol group as acceptor GO:0019158 mannokinase activity GO:0005634 nucleus GO:0005739 mitochondrion GO:0005741 mitochondrial outer membrane GO:0005773 vacuole GO:0005774 vacuolar membrane GO:0005829 cytosol GO:0009536 plastid GO:0016020 membrane GO:0016021 integral component of membrane
Organisms for which functions have been demonstratedArabidopsis thaliana
Sequence length496 amino acids
FASTA sequence>sp|Q42525|HXK1_ARATH Hexokinase-1 OS=Arabidopsis thaliana GN=HXK1 PE=1 SV=2 MGKVAVGATVVCTAAVCAVAVLVVRRRMQSSGKWGRVLAILKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNLPSGDEKGLFYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFVATECEDFHLPEGRQRELGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINMEWGNFRSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKMRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELLGDEASGSVEVTHSNDGSGIGAALLAASHSLYLEDS
Structure Information
PDB ID4QS7, 4QS9
Quaternary structure
Function 1
Function descriptionhexokinase, ATP + D-hexose => ADP + D-hexose 6-phosphate
References for functionMoore, Brandon, et al. "Role of the Arabidopsis glucose sensor HXK1 in nutrient, light, and hormonal signaling." Science300.5617 (2003): 332-336.
E.C. number2.7.1.1
Location of functional site(s)nucleotide binding: 101-106
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionbinds to vacuolar H+-ATPase B1 (VHA-B1) and the 19S regulatory particle of proteasome subunit (RPT5B) to modulate transcription of specific target genes
References for functionCho YH, Yoo SD, Sheen J. Regulatory functions of nuclear hexokinase1 complex in glucose signaling. Cell. 2006 Nov 3;127(3):579-89. PMID: 17081979
E.C. number
Location of functional site(s)
Cellular location of functionnucleus
Commentscatalytic activity not needed for this function