Protein Information

General Information
MoonProt ID36
First appeared in release1.0
Name(s)Enolase 2-phospho-D-glycerate hydro-lyase 2-phosphoglycerate dehydratase Gene Name: eno
UniProt IDQ97QS2
GO termsGO:0006096 glycolysis GO:0000287 magnesium ion binding GO:0004634 phosphopyruvate hydratase activity GO:0016829 lyase activity GO:0046872 metal ion binding GO:0000015 phosphopyruvate hydratase complex GO:0005576 extracellular region GO:0005737 cytoplasm GO:0009986 cell surface GO:0005515 protein binding
Organisms for which functions have been demonstratedStreptococcus pneumoniae
Sequence length434
FASTA sequence>sp|Q97QS2|ENO_STRPN Enolase OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) GN=eno PE=1 SV=1 MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGEHEAVELRDGDKSRYGGLGTQKAVDNVNNIIAEAIIGYDVRDQQAIDRAMIALDGTPNKGKLGANAILGVSIAVARAAADYLEIPLYSYLGGFNTKVLPTPMMNIINGGSHSDAPIAFQEFMILPVGAPTFKEALRYGAEIFHALKKILKSRGLETAVGDEGGFAPRFEGTEDGVETILAAIEAAGYVPGKDVFIGFDCASSEFYDKERKVYDYTKFEGEGAAVRTSAEQIDYLEELVNKYPIITIEDGMDENDWDGWKALTERLGKKVQLVGDDFFVTNTDYLARGIQEGAANSILIKVNQIGTLTETFEAIEMAKEAGYTAVVSHRSGETEDSTIADIAVATNAGQIKTGSLSRTDRIAKYNQLLRIEDQLGEVAEYRGLKSFYNLKK
Structure Information
PDB ID1W6T
Quaternary structure
Function 1
Function descriptionenolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysis
References for functionAntikainen J, Kuparinen V, L?hteenm?ki K, Korhonen TK. Enolases from Gram-positive bacterial pathogens and commensal lactobacilli share functional similarity in virulence-associated traits. FEMS Immunol Med Microbiol. 2007 Dec;;51(3):526-34.Epub 2007 Sep 24. PMID: 17892475.
E.C. number4.2.1.11
Location of functional site(s)Active site:205,343 Binding site:318,164,291,343,155,394 Metal binding site:242,291,318
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionbinds plasminogen
References for functionAntikainen J, Kuparinen V, L?hteenm?ki K, Korhonen TK. Enolases from Gram-positive bacterial pathogens and commensal lactobacilli share functional similarity in virulence-associated traits. FEMS Immunol Med Microbiol. 2007 Dec;51(3):526-34.Epub 2007 Sep 24. PMID: 17892475. Kolberg J, Aase A, Bergmann S, Herstad TK, R?dal G, Frank R, Rohde M, Hammerschmidt S. Streptococcus pneumoniae enolase is important for plasminogen binding despite low abundance of enolase protein on the bacterial cell surface. Microbiology. 2006 May;152(Pt 5):1307-17. PMID: 16622048.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments