Protein Information

General Information
MoonProt ID360
First appeared in release2.0
Name(s)Hgt1p, high-affinity glucose transporter 1, CaHgt1p Gene:HGT1
UniProt IDO74713 (HGT1_CANAX)
GO termsGO:0006810 transport GO:0008643 carbohydrate transport GO:0055085 transmembrane transport GO:0005215 transporter activity GO:0022857 transmembrane transporter activity GO:0022891 substrate-specific transmembrane transporter activity GO:0016020 membrane GO:0016021 integral component of membrane GO:0005515 protein binding
Organisms for which functions have been demonstratedCandida albicans
Sequence length545 amino acids
FASTA sequence>sp|O74713|HGT1_CANAX High-affinity glucose transporter OS=Candida albicans GN=HGT1 PE=3 SV=1 MSSKIERIFSGPALKINTYLDKLPKIYNVFFIASISTIAGMMFGFDISSMSAFIGAEHYMRYFNSPGSDIQGFITSSMALGSFFGSIASSFVSEPFGRRLSLLTCAFFWMVGAAIQSSVQNRAQLIIGRIISGIGVGFGSAVAPVYGAELAPRKIRGLIGGMFQFFVTLGIMIMFYLSFGLGHINGVASFRIAWGLQIVPGLCLFLGCFFIPESPRWLAKQGQWEAAEEIVAKIQAHGDRENPDVLIEISEIKDQLLLEESSKQIGYATLFTKKYIQRTFTAIFAQIWQQLTGMNVMMYYIVYIFQMAGYSGNSNLVASSIQYVINTCVTVPALYFIDKVGRRPLLIGGATMMMAFQFGLAGILGQYSIPWPDSGNDSVNIRIPEDNKSASKGAIACCYLFVASFAFTWGVGIWVYCAEIWGDNRVAQRGNAISTSANWILNFAIAMYTPTGFKNISWKTYIIYGVFCFAMATHVYFGFPETKGKRLEEIGQMWEERVPAWRSRSWQPTVPIASDAELARKMEVEHEEDKLMNEDSNSESRENQA
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionsugar transporter, glucose transporter
References for functionVarma A., Singh B.B., Karnani N., Lichtenberg-Frate H., Hofer M., Magee B.B., Prasad R. Molecular cloning and functional characterisation of a glucose transporter, CaHGT1, of Candida albicans. FEMS Microbiol. Lett. 182:15-21(2000). PMID: 10612724
E.C. number
Location of functional site(s)binding site: 99, 106, 138, 169, 248; active site: 193; nucleotide binding: 29-57
Cellular location of functiontransmembrane protein, cell membrane
Comments
Function 2
Function descriptioncomplement inhibitor, binds complement regulator FH, binds complement regulator C4BP, protects cells from host complement cascade, complement evasion resulting in reduced formation of the potentially lytic terminal complex (TCC)
References for functionLesiak-Markowicz I, Vogl G, Schwarzmuller T, Speth C, Lass-Florl C, Dierich MP, Kuchler K, Wurzner R. 2011. Candida albicans Hgt1p, a multifunctional evasion molecule: complement inhibitor, CR3 analogue, and human immunodeficiency virus-binding molecule. J Infect Dis 204:802-809.
E.C. number
Location of functional site(s)
Cellular location of functiontransmembrane protein, cell membrane
Comments