Protein Information

General Information
MoonProt ID364
First appeared in release2.0
Name(s)Inositol-pentakisphosphate 2-kinase, inositol 1,3,4,5,6-pentakisphosphate 2-kinase, Gene: IPPK
UniProt IDQ9H8X2 (IPPK_HUMAN)
GO termsGO:0016310 phosphorylation GO:0032958 inositol phosphate biosynthetic process GO:0043647 inositol phosphate metabolic process GO:0052746 inositol phosphorylation GO:0000166 nucleotide binding GO:0005524 ATP binding GO:0016301 kinase activity GO:0016740 transferase activity GO:0035299 inositol pentakisphosphate 2-kinase activity GO:0005622 intracellular GO:0005634 nucleus GO:0005654 nucleoplasm GO:0005737 cytoplasm GO:0005829 cytosol GO:0005515 protein binding GO:0032947 protein complex scaffold activity
Organisms for which functions have been demonstratedHomo sapiens (human)
Sequence length491 amino acids
FASTA sequence>sp|Q9H8X2|IPPK_HUMAN Inositol-pentakisphosphate 2-kinase OS=Homo sapiens GN=IPPK PE=1 SV=1 MEEGKMDENEWGYHGEGNKSLVVAHAQRCVVLRFLKFPPNRKKTSEEIFQHLQNIVDFGKNVMKEFLGENYVHYGEVVQLPLEFVKQLCLKIQSERPESRCDKDLDTLSGYAMCLPNLTRLQTYRFAEHRPILCVEIKPKCGFIPFSSDVTHEMKHKVCRYCMHQHLKVATGKWKQISKYCPLDLYSGNKQRMHFALKSLLQEAQNNLKIFKNGELIYGCKDARSPVADWSELAHHLKPFFFPSNGLASGPHCTRAVIRELVHVITRVLLSGSDKGRAGTLSPGLGPQGPRVCEASPFSRSLRCQGKNTPERSGLPKGCLLYKTLQVQMLDLLDIEGLYPLYNRVERYLEEFPEERKTLQIDGPYDEAFYQKLLDLSTEDDGTVAFALTKVQQYRVAMTAKDCSIMIALSPCLQDASSDQRPVVPSSRSRFAFSVSVLDLDLKPYESIPHQYKLDGKIVNYYSKTVRAKDNAVMSTRFKESEDCTLVLHKV
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionkinase, ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate => ADP + 1D-myo-inositol hexakisphosphate.
References for functionVerbsky, John W., et al. "The synthesis of inositol hexakisphosphate Characterization of human inositol 1, 3, 4, 5, 6-pentakisphosphate 2-kinase." Journal of Biological Chemistry 277.35 (2002): 31857-31862.
E.C. number2.7.1.158
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionscaffold, binds protein kinase CK2, TCOF1, and upstream-binding-factor (UBF)
References for functionBrehm MA1, Wundenberg T, Williams J, Mayr GW, Shears SB. A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA. J Cell Sci. 2013 Jan 15;126(Pt 2):437-44. doi: 10.1242/jcs.110031. PMID: 23203802.
E.C. number
Location of functional site(s)
Cellular location of functionnucleus, nucleolus
Comments